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    eEF1alpha2 eukaryotic translation elongation factor 1 alpha 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eEF1alpha2provided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0000557
    Locus tag
    Dmel_CG1873
    See related
    AllianceGenome:FB:FBgn0000557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1873; Dmel\CG1873; eEF1; eEF1alpha; EF-1; ef-1alpha; EF-1alpha; EF-1alpha F2; Ef1 alpha100E; EF1-a 100E; EF1-alpha; EF1a; EF1A; Ef1a-100E; Ef1a48; EF1alpha; EF1alpha100; Ef1alpha100E; Ef1alpha2; Efla2; F2
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEF1alpha2 in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31738468..31743306)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27564190..27569028)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cleavage stimulation factor 50 kD subunit Neighboring gene uncharacterized protein Neighboring gene Tubulin binding cofactor A Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Shepherd JC, et al. Proc Natl Acad Sci U S A, 1989 Oct. PMID 2508089, Free PMC Article
    2. F1 and F2: Two similar genes regulated differently during development of Drosophila melanogaster. Walldorf U, et al. Proc Natl Acad Sci U S A, 1985 Sep. PMID 16593598, Free PMC Article
    3. The expression of the EF1 alpha genes of Drosophila is not associated with the extended longevity phenotype in a selected long-lived strain. Dudas SP, et al. Exp Gerontol, 1994 Nov-Dec. PMID 9435916
    4. Genetic analysis of mechanisms of aging. Rose MR, et al. Curr Opin Genet Dev, 1996 Jun. PMID 8791514
    5. eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle. Katow H, et al. Dis Model Mech, 2024 Sep 1. PMID 39207054, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eEF1alpha2 is required for actin cytoskeleton homeostasis in the aging muscle.
      Title: eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of eukaryotic translation elongation factor 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 alpha 2
    Names
    CG1873-PA
    CG1873-PB
    CG1873-PC
    CG1873-PD
    ELONGATION FACTOR 1-ALPHA 2
    S
    eEF1alpha2-PA
    eEF1alpha2-PB
    eEF1alpha2-PC
    eEF1alpha2-PD
    elongation factor 1-alpha
    elongation factor 1-alpha F2
    elongation factor 1alpha 100E
    elongation factor 1alpha100E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31738468..31743306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079872.4 → NP_524611.1  eukaryotic translation elongation factor 1 alpha 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05303, Q9V9U8
      UniProtKB/TrEMBL
      A4V3Q6
      Related
      FBpp0085193, FBtr0085832
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 450
      PTZ00141; elongation factor 1- alpha; Provisional

    2. NM_206592.1 → NP_996315.1  eukaryotic translation elongation factor 1 alpha 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05303, Q9V9U8
      UniProtKB/TrEMBL
      A4V3Q6
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 450
      PTZ00141; elongation factor 1- alpha; Provisional

    3. NM_170570.1 → NP_733449.1  eukaryotic translation elongation factor 1 alpha 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05303, Q9V9U8
      UniProtKB/TrEMBL
      A4V3Q6
      Related
      FBpp0085194, FBtr0085833
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 450
      PTZ00141; elongation factor 1- alpha; Provisional

    4. NM_206593.1 → NP_996316.1  eukaryotic translation elongation factor 1 alpha 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05303, Q9V9U8
      UniProtKB/TrEMBL
      A4V3Q6
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 450
      PTZ00141; elongation factor 1- alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V3Q6 A4V3Q6
    P05303.2 P05303

    Gene LinkOut

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