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    APOC2 apolipoprotein C2 [ Canis lupus familiaris (dog) ]

    Gene ID: 442969, updated on 17-Aug-2024

    Summary

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    Official Symbol
    APOC2provided by VGNC
    Official Full Name
    apolipoprotein C2provided by VGNC
    Primary source
    VGNC:VGNC:56913
    See related
    Ensembl:ENSCAFG00845006579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    APOCII; Apo-CII; ApoC-II
    Orthologs
    human mouse all
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    Genomic context

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    See APOC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (111034576..111036727, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (109985886..109987967, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (111213632..111215715, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (110709344..110711427, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (110344763..110346846, complement)

    Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene RELB proto-oncogene, NF-kB subunit Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking Neighboring gene uncharacterized LOC119864862 Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of dog apolipoprotein C-II and C-III mRNAs. Implications for the evolution and functional constraints of apolipoprotein structure. Datta S, et al. J Biol Chem, 1987 Aug 5. PMID 2956259
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipoprotein lipase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chylomicron remnant clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in high-density lipoprotein particle clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of very-low-density lipoprotein particle clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of lipoprotein lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chylomicron IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of intermediate-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of spherical high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apolipoprotein C-II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003368.1 → NP_001003368.1  apolipoprotein C-II precursor

      See identical proteins and their annotated locations for NP_001003368.1

      Status: PROVISIONAL

      Source sequence(s)
      M17177
      UniProtKB/Swiss-Prot
      P12278
      UniProtKB/TrEMBL
      A0A8C0KH95
      Conserved Domains (1) summary
      pfam05355
      Location:24 → 100
      Apo-CII; Apolipoprotein C-II

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051805.1 Reference ROS_Cfam_1.0

      Range
      111034576..111036727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038653453.1 → XP_038509381.1  apolipoprotein C-II isoform X1

      UniProtKB/Swiss-Prot
      P12278
      UniProtKB/TrEMBL
      A0A8C0KH95
      Related
      ENSCAFP00845009125.1, ENSCAFT00845011687.1
      Conserved Domains (1) summary
      pfam05355
      Location:24 → 100
      Apo-CII; Apolipoprotein C-II

    2. XM_038653454.1 → XP_038509382.1  apolipoprotein C-II isoform X2

      Conserved Domains (1) summary
      pfam05355
      Location:40 → 116
      Apo-CII; Apolipoprotein C-II

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049261.1 Alternate UMICH_Zoey_3.1

      Range
      110709344..110711427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

      Range
      110344763..110346846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

      Range
      111213632..111215715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      109985886..109987967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12278.1 GenPept UniProtKB/Swiss-Prot:P12278

    Gene LinkOut

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