CanB Calcineurin B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CanBprovided by FlyBase
Official Full Name: Calcineurin Bprovided by FlyBase
Primary source: FLYBASE:FBgn0010014
Locus tag: Dmel_CG4209
See related: AllianceGenome:FB:FBgn0010014
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH11383; Can; CaN; canB; CaNB; canB-4F; CG4209; CnB; CNB; dCnB1; Dmel\CG4209
Summary: Predicted to enable several functions, including calcium ion binding activity; calcium-dependent protein serine/threonine phosphatase regulator activity; and calmodulin binding activity. Involved in sleep. Predicted to be part of calcineurin complex. Is expressed in several structures, including adult head; adult optic lobe; brain; embryonic head sensory system; and larval nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to several human genes including PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5332499..5334449)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5226532..5228482)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in sleep	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

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