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    flii.S FLII actin remodeling protein S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444748, updated on 4-Jan-2025

    Summary

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    Official Symbol
    flii.S
    Official Full Name
    FLII actin remodeling protein S homeolog
    Primary source
    Xenbase:XB-GENE-865203
    Locus tag
    XELAEV_18047790mg
    See related
    EnsemblRapid:ENSXLAG00005011103 AllianceGenome:Xenbase:XB-GENE-865203
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    flii; flightless
    Summary
    Predicted to enable actin filament binding activity. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See flii.S in Genome Data Viewer
    Location:
    chromosome: 9_10S
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (105971567..106010219, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (99327634..99366621, complement)

    Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene alkB homolog 5, RNA demethylase S homeolog Neighboring gene LLGL1, scribble cell polarity complex component S homeolog Neighboring gene mitochondrial elongation factor 2 S homeolog Neighboring gene Smith-Magenis syndrome chromosome region, candidate 8 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC84783

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FLII actin remodeling protein S homeolog
    Names
    flightless 1 homolog
    flightless I actin binding protein S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092850.1 → NP_001086319.1  FLII actin remodeling protein S homeolog

      See identical proteins and their annotated locations for NP_001086319.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074479
      UniProtKB/TrEMBL
      A0A974BVY6, Q6DKA2
      Related
      ENSXLAP00005032637.1, ENSXLAT00005033429.1
      Conserved Domains (8) summary
      cd11280
      Location:620 → 707
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1054 → 1153
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:493 → 605
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:1164 → 1262
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:724 → 838
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      PLN00113
      Location:5 → 352
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:342 → 355
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:106 → 128
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      105971567..106010219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018237491.2 → XP_018092980.1  FLII actin remodeling protein S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0TXX1, A0A974BVY6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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