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    klkb1.L kallikrein B1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 446603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klkb1.L
    Official Full Name
    kallikrein B1 L homeolog
    Primary source
    Xenbase:XB-GENE-985054
    Locus tag
    XELAEV_18005339mg
    See related
    EnsemblRapid:ENSXLAG00005005716 AllianceGenome:Xenbase:XB-GENE-985054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    klkb1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klkb1.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (46138136..46164725, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (36897982..36923901, complement)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 1 L homeolog Neighboring gene melatonin receptor 1A L homeolog Neighboring gene cytochrome P450, family 4, subfamily V, polypeptide 4 Neighboring gene cytochrome P450 family 4 subfamily V member 2, gene 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC82165

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plasma kallikrein B1
    Names
    kallikrein B, plasma (Fletcher factor) 1
    NP_001086768.1
    XP_041436868.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093299.1 → NP_001086768.1  plasma kallikrein B1 precursor

      See identical proteins and their annotated locations for NP_001086768.1

      Status: PROVISIONAL

      Source sequence(s)
      BC077417
      UniProtKB/TrEMBL
      A0A974I2J2, Q6AZS7
      Related
      ENSXLAP00005017017.1, ENSXLAT00005017313.1
      Conserved Domains (3) summary
      smart00223
      Location:21 → 103
      APPLE; APPLE domain
      smart00020
      Location:390 → 623
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:391 → 626
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      46138136..46164725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041580934.1 → XP_041436868.1  plasma kallikrein B1 isoform X1

      UniProtKB/TrEMBL
      A0A8J1M5A3
      Related
      ENSXLAP00005017021.1, ENSXLAT00005017316.1
      Conserved Domains (2) summary
      smart00223
      Location:21 → 103
      APPLE; APPLE domain
      cd00190
      Location:391 → 626
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version

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