tp53bp2.L tumor protein p53 binding protein 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tp53bp2.L
Official Full Name: tumor protein p53 binding protein 2 L homeolog
Primary source: Xenbase:XB-GENE-962020
Locus tag: XELAEV_18026271mg
See related: EnsemblRapid:ENSXLAG00005031349 AllianceGenome:Xenbase:XB-GENE-962020
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tp53bp2
Summary: Predicted to enable p53 binding activity. Predicted to act upstream of or within apoptotic process; regulation of apoptotic process; and signal transduction. Predicted to be located in nucleus. Is expressed in ectoderm; mesenchyme; nervous system; vestibuloauditory system; and visual system. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 5L

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (17101845..17137522, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (16402292..16438165, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables p53 binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor protein p53 binding protein 2 L homeolog

Names: tumor protein p53 binding protein, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093615.1 → NP_001087084.1 tumor protein p53 binding protein 2 L homeolog

See identical proteins and their annotated locations for NP_001087084.1

Status: PROVISIONAL

Source sequence(s)

BC128681

UniProtKB/TrEMBL

A1A5J5, Q66IP5

Related

ENSXLAP00005094086.1, ENSXLAT00005095788.1

Conserved Domains (7) summary

cd11953
Location:1043 → 1099

SH3_ASPP2; Src Homology 3 (SH3) domain of Apoptosis Stimulating of p53 protein 2

cd00204
Location:919 → 1030

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam02050
Location:210 → 318

FliJ; Flagellar FliJ protein

pfam10473
Location:169 → 305

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

pfam12796
Location:913 → 1004

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:913 → 939

ANK; ANK repeat [structural motif]

cl00155
Location:2 → 78

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

17101845..17137522 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041562223.1 → XP_041418157.1 tumor protein p53 binding protein 2 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1KLF6, Q66IP5

Related

ENSXLAP00005094352.1, ENSXLAT00005096054.1

Conserved Domains (5) summary

cd11953
Location:1043 → 1099

SH3_ASPP2; Src Homology 3 (SH3) domain of Apoptosis Stimulating of p53 protein 2

COG1196
Location:148 → 319

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

sd00045
Location:913 → 939

ANK; ANK repeat [structural motif]

cd17225
Location:1 → 80

RA_ASPP2; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 2 (ASPP2)

pfam13637
Location:944 → 995

Ank_4; Ankyrin repeats (many copies)
XM_018261981.2 → XP_018117470.1 tumor protein p53 binding protein 2 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J0V9T4, Q66IP5

Related

ENSXLAP00005093938.1, ENSXLAT00005095640.1