msk moleskin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mskprovided by FlyBase
Official Full Name: moleskinprovided by FlyBase
Primary source: FLYBASE:FBgn0026252
Locus tag: Dmel_CG7935
See related: AllianceGenome:FB:FBgn0026252
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 61; CG7935; CIP-61; dim-7; Dim-7; DIM-7; dim7; Dim7; Dmel\CG7935; DmRanBP7; Imp 7; Imp7; Imp7/8; Msk; S(ls)2
Summary: Enables U1 snRNA binding activity; U2 snRNA binding activity; and U4 snRNA binding activity. Involved in several processes, including Cajal body organization; compound eye morphogenesis; and wing disc development. Located in several cellular components, including Cajal body; cell cortex; and perinuclear region of cytoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; larval muscle cell; and mesoderm. Orthologous to several human genes including IPO7 (importin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66B6-66B6; 3-22 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8116179..8121579)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8109279..8114679)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DIM-7 is involved specifically in regulation of consolidation of protein-synthesis-dependent long-term memory in mushroom body neurons.
Title: Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.
The importin-7 orthologue Moleskin (Msk) physically associates with both dSNUP and spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and localizes to nuclear Cajal bodies.
Title: Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesis.
Our results show that integrins function as upstream signals to mediate Dim7-Elmo enrichment to the muscle attachment sites .
Title: Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.
Msk is required for muscle-tendon attachment.
Title: "Importin" signaling roles for import proteins: the function of Drosophila importin-7 (DIM-7) in muscle-tendon signaling.
Findings provide strong evidence that Msk signals non-autonomously through the Vein-Egfr signaling pathway for late tendon cell late differentiation and/or maintenance.
Title: Moleskin is essential for the formation of the myotendinous junction in Drosophila.
moleskin (msk) is important for the nuclear import of phosphorylated Mad.
Title: Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.
These data suggest a model in which ERK phosphorylation must be spatially coupled to integrin-mediated DIM-7 activation to make a complex that can be imported efficiently.
Title: Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.
Delta loss-of-function alleles dominantly suppress Msk gain-of-function phenotypes in the developing wing.
Title: Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development.
Moleskin antigen, a MAP kinase transport factor, is sequestered apically at a time when lateral inhibition is required for patterning in the developing eye.
Title: smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye.
interaction with PS1 and PS2 integrins
Title: Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables U1 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U4 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in R8 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ommatidial rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: moleskin

Names: CG7935-PA; Importin-7; corkscrew interacting Protein-61; diminished-7; drosophila Importin-7; msk-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8116179..8121579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_080041.3 → NP_524780.1 moleskin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524780.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KIF8, Q86NK4, Q9VSD6

Related

FBpp0076408

Conserved Domains (2) summary

COG5656
Location:4 → 1013

SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

pfam03810
Location:24 → 103

IBN_N; Importin-beta N-terminal domain