cdkn2b cyclin-dependent kinase inhibitor 2B [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: cdkn2bprovided by Xenbase
Official Full Name: cyclin-dependent kinase inhibitor 2Bprovided by Xenbase
Primary source: Xenbase:XB-GENE-478746
See related: Ensembl:ENSXETG00000005465 AllianceGenome:Xenbase:XB-GENE-478746
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: p15; mts2; tp15; cdk4l; ink4b; p15ink4b
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); high grade glioma (multiple); and melanoma (multiple). Orthologous to several human genes including CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (121217673..121223546, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (108982141..108988014, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 4 inhibitor B

Names: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.