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    clbB colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [ Citrobacter koseri ATCC BAA-895 ]

    Gene ID: 45135051, updated on 3-Dec-2024

    Summary

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    Gene symbol
    clbB
    Gene description
    colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB
    Locus tag
    CKO_RS03750
    Gene type
    protein coding
    Organism
    Citrobacter koseri ATCC BAA-895 (strain: ATCC BAA-895)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Citrobacter
    Old locus tag
    CKO_00859
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    Genomic context

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    Sequence:
    NC_009792.1 (819512..829132)

    NC_009792.1Genomic Context describing neighboring genes Neighboring gene colibactin biosynthesis phosphopantetheinyl transferase ClbA Neighboring gene colibactin biosynthesis LuxR family transcriptional regulator ClbR Neighboring gene colibactin polyketide synthase ClbC Neighboring gene colibactin biosynthesis dehydrogenase ClbD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009792.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways. Engel P, et al. Appl Environ Microbiol, 2015 Feb. PMID 25527542, Free PMC Article
    2. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Nougayrède JP, et al. Science, 2006 Aug 11. PMID 16902142

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009792.1 Reference assembly

      Range
      819512..829132
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_001518711.1 MULTISPECIES: colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [Enterobacterales]

      See identical proteins and their annotated locations for WP_001518711.1

      UniProtKB/TrEMBL
      A0A454A533, A0AAQ1A4Q3, A0AAW9DX02, Q0P7J2, S1PZX1
      Conserved Domains (6) summary
      cd08953
      Location:2040 → 2422
      KR_2_SDR_x; ketoreductase (KR), subgroup 2, complex (x) SDRs
      smart00829
      Location:2710 → 2996
      PKS_ER; Enoylreductase
      COG3321
      Location:1083 → 2081
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      PRK12316
      Location:3079 → 3159
      PRK12316; peptide synthase; Provisional
      PRK12467
      Location:4 → 1062
      PRK12467; peptide synthase; Provisional
      cl00509
      Location:2408 → 2649
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...

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