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    PRKRA protein activator of interferon induced protein kinase EIF2AK2 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 459776, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRKRAprovided by VGNC
    Official Full Name
    protein activator of interferon induced protein kinase EIF2AK2provided by VGNC
    Primary source
    VGNC:VGNC:6371
    Locus tag
    CK820_G0001621
    See related
    Ensembl:ENSPTRG00000012688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See PRKRA in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (80462035..80481356, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (80461998..80481247, complement)

    Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene oxysterol binding protein like 6 Neighboring gene uncharacterized LOC112208386 Neighboring gene nuclear migration protein nudC-like Neighboring gene pejvakin Neighboring gene FKBP prolyl isomerase 7 Neighboring gene pleckstrin homology domain containing A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables siRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of regulatory ncRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in siRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of RISC-loading complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-inducible double-stranded RNA-dependent protein kinase activator A
    Names
    interferon-inducible double stranded RNA-dependent protein kinase activator A
    protein kinase, interferon-inducible double stranded RNA dependent activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001279769.1 → NP_001266698.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A

      See identical proteins and their annotated locations for NP_001266698.1

      Status: PROVISIONAL

      Source sequence(s)
      AK306717
      UniProtKB/TrEMBL
      A0A2I3SAI2, G2HJ03
      Conserved Domains (2) summary
      smart00358
      Location:10 → 75
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:101 → 167
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      80462035..80481356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009443668.5 → XP_009441943.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X1

      See identical proteins and their annotated locations for XP_009441943.1

      UniProtKB/TrEMBL
      A0A2I3SAI2, A0A2J8PRE1, A0A6D2WC05, H2QJ21
      Related
      ENSPTRP00000021685.5
      Conserved Domains (3) summary
      cd19889
      Location:32 → 102
      DSRM_PRKRA_rpt1; first double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19891
      Location:126 → 192
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19892
      Location:239 → 310
      DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins

    2. XM_063790241.1 → XP_063646311.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2

    3. XM_016949333.4 → XP_016804822.1  interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform X2

      Conserved Domains (2) summary
      cd19891
      Location:41 → 107
      DSRM_PRKRA_rpt2; second double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
      cd19892
      Location:154 → 225
      DSRM_PRKRA_rpt3; third double-stranded RNA binding motif of protein activator of the interferon-induced protein kinase (PRKRA) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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