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    Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498486, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gnpnat1provided by RGD
    Official Full Name
    glucosamine-phosphate N-acetyltransferase 1provided by RGD
    Primary source
    RGD:1563144
    See related
    EnsemblRapid:ENSRNOG00000008641 AllianceGenome:RGD:1563144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563144
    Summary
    Enables glucosamine 6-phosphate N-acetyltransferase activity and monosaccharide binding activity. Involved in N-acetylglucosamine metabolic process; glucosamine metabolic process; and liver development. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 318.7), Kidney (RPKM 174.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gnpnat1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (21076129..21088526, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18596180..18608854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19721292..19734032, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 like 6 Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene farnesyl diphosphate synthase pseudogene Neighboring gene serine/threonine/tyrosine interacting protein Neighboring gene U6 spliceosomal RNA Neighboring gene FERM domain containing kindlin 2 Neighboring gene ribosomal protein S29, pseudogene 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Three forms of rat liver glucosamine 6-phosphate acetylase and the changes in their levels during development. Oikawa S, et al. Int J Biochem, 1985. PMID 3996734
    2. Glucosamine 6-phosphate acetylase in rat ascites hepatomas. Oikawa S, et al. Int J Biochem, 1986. PMID 3792612
    3. Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1. Wang J, et al. FEBS Lett, 2008 Sep 3. PMID 18675810
    4. Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association. Boehmelt G, et al. J Biol Chem, 2000 Apr 28. PMID 10777580
    5. The cellular fate of glucose and its relevance in type 2 diabetes. Bouché C, et al. Endocr Rev, 2004 Oct. PMID 15466941

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucosamine 6-phosphate N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucosamine 6-phosphate N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucosamine 6-phosphate N-acetyltransferase
    NP_001128228.1
    NP_001128229.1
    XP_006251846.1
    XP_063130616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134756.1 → NP_001128228.1  glucosamine 6-phosphate N-acetyltransferase

      See identical proteins and their annotated locations for NP_001128228.1

      Status: VALIDATED

      Source sequence(s)
      AI502591, BC160861, CA339205
      UniProtKB/TrEMBL
      A0A8I6AKF3, A6KDZ8, B1H249, F7EV78
      Related
      ENSRNOP00000012036.3, ENSRNOT00000012036.8
      Conserved Domains (1) summary
      cl17182
      Location:36 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_001134757.1 → NP_001128229.1  glucosamine 6-phosphate N-acetyltransferase

      See identical proteins and their annotated locations for NP_001128229.1

      Status: VALIDATED

      Source sequence(s)
      AI502591, BC160861
      UniProtKB/TrEMBL
      A0A8I6AKF3, A6KDZ8, B1H249, F7EV78
      Conserved Domains (1) summary
      cl17182
      Location:36 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      21076129..21088526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251784.5 → XP_006251846.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006251846.1

      UniProtKB/TrEMBL
      A0A8I6AKF3, A6KDZ8, B1H249, F7EV78
      Conserved Domains (1) summary
      cl17182
      Location:36 → 174
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. XM_063274546.1 → XP_063130616.1  glucosamine 6-phosphate N-acetyltransferase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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