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    Pwwp3b PWWP domain containing 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pwwp3bprovided by RGD
    Official Full Name
    PWWP domain containing 3Bprovided by RGD
    Primary source
    RGD:1565148
    See related
    EnsemblRapid:ENSRNOG00000030475 AllianceGenome:RGD:1565148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mum1l1; RGD1565148
    Summary
    Orthologous to human PWWP3B (PWWP domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 37.6), Muscle (RPKM 34.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pwwp3b in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107593062..107627215)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (102804416..102838580)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (110375434..110411221)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene serpin family A member 7 Neighboring gene glutamic acid-rich protein-like Neighboring gene uncharacterized LOC108349242 Neighboring gene uncharacterized LOC103690886 Neighboring gene tumor rejection antigen P1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis. Jha P, et al. J Biol Chem, 2009 Nov 6. PMID 19755419, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAA, a proteolytic cleavage fragment of type I collagen alpha2 chain, is an autoantigen in autoimmune anterior uveitis.
      Title: Proteolytic cleavage of type I collagen generates an autoantigen in autoimmune uveitis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    PWWP domain-containing DNA repair factor 3B
    Names
    MUM1 like 1
    PWWP domain-containing protein MUM1L1
    melanoma associated antigen (mutated) 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109321.2 → NP_001102791.1  PWWP domain-containing DNA repair factor 3B

      See identical proteins and their annotated locations for NP_001102791.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9
      Conserved Domains (1) summary
      cd06080
      Location:373 → 452
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    2. NM_001434345.1 → NP_001421274.1  PWWP domain-containing DNA repair factor 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    3. NM_001434346.1 → NP_001421275.1  PWWP domain-containing DNA repair factor 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    4. NM_001434347.1 → NP_001421276.1  PWWP domain-containing DNA repair factor 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    5. NM_001434348.1 → NP_001421277.1  PWWP domain-containing DNA repair factor 3B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      107593062..107627215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257305.5 → XP_006257367.1  PWWP domain-containing DNA repair factor 3B isoform X1

      Related
      ENSRNOP00000107757.1, ENSRNOT00000123268.1
      Conserved Domains (1) summary
      cd06080
      Location:373 → 452
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    2. XM_006257301.4 → XP_006257363.1  PWWP domain-containing DNA repair factor 3B isoform X1

      Related
      ENSRNOP00000105135.1, ENSRNOT00000140999.1
      Conserved Domains (1) summary
      cd06080
      Location:373 → 452
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    3. XM_063280257.1 → XP_063136327.1  PWWP domain-containing DNA repair factor 3B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    4. XM_063280256.1 → XP_063136326.1  PWWP domain-containing DNA repair factor 3B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKW6, A6KNX2, B5DEG0, F6QZQ9

    5. XM_006257303.4 → XP_006257365.1  PWWP domain-containing DNA repair factor 3B isoform X1

      Related
      ENSRNOP00000112100.1, ENSRNOT00000164023.1
      Conserved Domains (1) summary
      cd06080
      Location:373 → 452
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

    6. XM_063280255.1 → XP_063136325.1  PWWP domain-containing DNA repair factor 3B isoform X1

    7. XM_006257304.4 → XP_006257366.1  PWWP domain-containing DNA repair factor 3B isoform X1

      Related
      ENSRNOP00000111756.1, ENSRNOT00000157017.1
      Conserved Domains (1) summary
      cd06080
      Location:373 → 452
      MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
    Nucleotide Protein Strain
    Heading Accession and Version

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