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    schlank schlank [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    schlankprovided by FlyBase
    Official Full Name
    schlankprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040918
    Locus tag
    Dmel_CG3576
    See related
    AllianceGenome:FB:FBgn0040918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CerS; CG15898; CG3576; Dlag1; DLag1; DLAG1; Dmel\CG3576; Iag1; l(1)G0061; l(1)G0365; l(1)G0489; lag1; Lag1; lon; Schlank
    Summary
    Enables sphingosine N-acyltransferase activity. Involved in several processes, including SREBP signaling pathway; ceramide biosynthetic process; and regulation of lipid metabolic process. Located in endoplasmic reticulum and nuclear inner membrane. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; glial cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to several human genes including CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See schlank in Genome Data Viewer
    Location:
    5E3-5E4; 1-16 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6257668..6267228, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6151701..6161261, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rabconnectin-3A Neighboring gene Spliceosomal protein on the X Neighboring gene Josephin domain containing Neighboring gene Spt6 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-5E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS. Voelzmann A, et al. Gene Expr Patterns, 2011 Dec. PMID 21907829
    2. Towards understanding regulation of energy homeostasis by ceramide synthases. Bauer R. Results Probl Cell Differ, 2010. PMID 20865380
    3. Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk. Li Y, et al. Gastroenterology, 2023 Nov. PMID 37541526, Free PMC Article
    4. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. Jung WH, et al. EMBO Rep, 2017 Jul. PMID 28507162, Free PMC Article
    5. Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. Voelzmann A, et al. FEBS Lett, 2016 Apr. PMID 26950647

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the homeodomain of Schlank is involved in the regulation of lipid metabolism in fat bodies; this regulation is independent of the catalytic lag1p motif of Schlank active site; Schlank homeodomain mediates nuclear localization.
      Title: Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif.
    2. Schlank is upregulated in the developing central (CNS) and peripheral nervous system (PNS). Co-staining experiments with neuronal and glial markers revealed specific expression of Schlank in glial and neuronal cells of the CNS and PNS.
      Title: Embryonic expression of Drosophila ceramide synthase schlank in developing gut, CNS and PNS.
    3. Schlank encodes a conserved member of the Lass/CerS family of ceramide synthases , which contain a catalytic Lag1 motif and a homeobox transcription factor domain
      Title: Towards understanding regulation of energy homeostasis by ceramide synthases.
    4. results identify schlank (aka Lag1) as a new regulator of the balance between lipogenesis and lipolysis in Drosophila
      Title: Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    schlank
    Names
    CG3576-PA
    CG3576-PB
    Psc
    longevity
    longevity assurance gene 1
    schlank-PA
    schlank-PB
    NP_652526.1
    NP_727075.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6257668..6267228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167063.3 → NP_727075.1  schlank, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RN6, Q9W423
      Related
      FBpp0070898
      Conserved Domains (2) summary
      smart00724
      Location:135 → 334
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:75 → 131
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    2. NM_144269.4 → NP_652526.1  schlank, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RN6, Q9W423
      Related
      FBpp0070899
      Conserved Domains (2) summary
      smart00724
      Location:135 → 334
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:75 → 131
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W423 Q9W423

    Gene LinkOut

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