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    SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 [ Homo sapiens (human) ]

    Gene ID: 50859, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SPOCK3provided by HGNC
    Official Full Name
    SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3provided by HGNC
    Primary source
    HGNC:HGNC:13565
    See related
    Ensembl:ENSG00000196104 MIM:607989; AllianceGenome:HGNC:13565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TES-3; TICN3; HSAJ1454
    Summary
    This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Biased expression in brain (RPKM 28.5), prostate (RPKM 28.2) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPOCK3 in Genome Data Viewer
    Location:
    4q32.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (166733384..167234945, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (170090608..170592260, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (167654535..168155645, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377521 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:166888016-166889215 Neighboring gene Sharpr-MPRA regulatory region 2915 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:166963784-166964983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22120 Neighboring gene tolloid like 1 Neighboring gene RNA, 5S ribosomal pseudogene 170 Neighboring gene Sharpr-MPRA regulatory region 13283 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75833 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75852 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75875 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75970 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75989 Neighboring gene Sharpr-MPRA regulatory region 523 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76035 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:167491405-167492062 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:167490745-167491404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22121 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:167636733-167637577 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:167637578-167638421 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:167642620-167643500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22122 Neighboring gene NANOG hESC enhancer GRCh37_chr4:167796983-167797484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15787 Neighboring gene RNA, 5S ribosomal pseudogene 171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22123 Neighboring gene RNA, 7SL, cytoplasmic 776, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:168508591-168509790 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76084 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76088 Neighboring gene PHB1 pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Mechanism of prognostic marker SPOCK3 affecting malignant progression of prostate cancer and construction of prognostic model. Luo J, et al. BMC Cancer, 2023 Aug 11. PMID 37563543, Free PMC Article
    2. Testican 3 expression in adult T-cell leukemia. Kamioka M, et al. Leuk Res, 2009 Jul. PMID 19144404
    3. SPOCK3, a risk gene for adult ADHD and personality disorders. Weber H, et al. Eur Arch Psychiatry Clin Neurosci, 2014 Aug. PMID 24292267
    4. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Debette S, et al. Biol Psychiatry, 2015 Apr 15. PMID 25648963, Free PMC Article
    5. SPOCK: Master regulator of malignant tumors (Review). Xiao M, et al. Mol Med Rep, 2024 Dec. PMID 39392048, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPOCK: Master regulator of malignant tumors (Review).
      Title: SPOCK: Master regulator of malignant tumors (Review).
    2. Proteins linking APOE varepsilon4 with Alzheimer's disease.
      Title: Proteins linking APOE ɛ4 with Alzheimer's disease.
    3. Mechanism of prognostic marker SPOCK3 affecting malignant progression of prostate cancer and construction of prognostic model.
      Title: Mechanism of prognostic marker SPOCK3 affecting malignant progression of prostate cancer and construction of prognostic model.
    4. associations, near SPOCK3 were identified and other putative modulators of memory performance were revealed by a
      Title: Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.
    5. The results of this study suggest that SPOCK3 may modify the genetic risk for Attention-deficit/hyperactivity disorder and personality disorders
      Title: SPOCK3, a risk gene for adult ADHD and personality disorders.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. High expression of testican 3 is associated with adult T-cell leukemia.
      Title: Testican 3 expression in adult T-cell leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell motility TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of endopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix HDA PubMed 
    located_in extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testican-3
    Names
    SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030414.1 RefSeqGene

      Range
      5097..506207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040159.2 → NP_001035249.1  testican-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001035249.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AC020599, BC003017
      Consensus CDS
      CCDS34095.1
      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000350153.4, ENST00000357545.9
      Conserved Domains (3) summary
      smart00280
      Location:137 → 180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:313 → 377
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16239
      Location:198 → 310
      EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)

    2. NM_001204352.2 → NP_001191281.1  testican-3 isoform 3

      See identical proteins and their annotated locations for NP_001191281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon, includes an alternate exon in the 5' coding region, and uses an alternate start codon, compared to variant 2. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295015, BI603782
      Consensus CDS
      CCDS56344.1
      UniProtKB/TrEMBL
      B4DI52
      Related
      ENSP00000411344.2, ENST00000421836.6
      Conserved Domains (4) summary
      smart00280
      Location:89 → 132
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:265 → 329
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:149 → 268
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:148 → 255
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    3. NM_001204353.1 → NP_001191282.1  testican-3 isoform 4

      See identical proteins and their annotated locations for NP_001191282.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons and uses a downstream, in-frame start codon, compared to variant 2. The encoded isoform (4) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295407
      Consensus CDS
      CCDS56343.1
      UniProtKB/TrEMBL
      B4DI52
      Related
      ENSP00000444789.1, ENST00000541354.5
      Conserved Domains (4) summary
      smart00280
      Location:20 → 63
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:196 → 260
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:80 → 199
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:79 → 186
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    4. NM_001204354.2 → NP_001191283.1  testican-3 isoform 5

      See identical proteins and their annotated locations for NP_001191283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons and uses a downstream, in-frame start codon, compared to variant 2. The encoded isoform (5) has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK091078, AK295414
      Consensus CDS
      CCDS75207.1
      UniProtKB/TrEMBL
      A0A0A0MTJ2, B4DI52
      Related
      ENSP00000441396.2, ENST00000535728.5
      Conserved Domains (4) summary
      smart00280
      Location:48 → 91
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:224 → 288
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:108 → 227
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:107 → 214
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    5. NM_001204355.2 → NP_001191284.1  testican-3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three consecutive coding exons and uses an alternate start codon, compared to variant 2. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC020599, AK295281, BI603782
      UniProtKB/TrEMBL
      B4DI52
      Conserved Domains (4) summary
      smart00280
      Location:44 → 87
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:220 → 284
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:104 → 223
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:103 → 210
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    6. NM_001204356.2 → NP_001191285.1  testican-3 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 2. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AC020599, AK296291, BI603782
      Consensus CDS
      CCDS56346.1
      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000426716.1, ENST00000510741.5
      Conserved Domains (3) summary
      smart00280
      Location:137 → 180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:273 → 337
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:195 → 276
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

    7. NM_001204358.2 → NP_001191287.1  testican-3 isoform 9 precursor

      See identical proteins and their annotated locations for NP_001191287.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (9, also known as N-TES) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 2.
      Source sequence(s)
      AB056866, AC020599
      Consensus CDS
      CCDS56347.1
      UniProtKB/Swiss-Prot
      Q9BQ16
      Related
      ENSP00000426177.1, ENST00000512648.5
      Conserved Domains (3) summary
      smart00280
      Location:137 → 180
      KAZAL; Kazal type serine protease inhibitors
      cd00252
      Location:197 → 311
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:196 → 303
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    8. NM_001251967.2 → NP_001238896.1  testican-3 isoform 11 precursor

      See identical proteins and their annotated locations for NP_001238896.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks four consecutive coding exons but maintains the reading frame, compared to variant 2. The encoded isoform (11) is shorter than isoform 2.
      Source sequence(s)
      AC020599, AK294637, BI603782
      Consensus CDS
      CCDS58931.1
      UniProtKB/TrEMBL
      B4DI52
      Related
      ENSP00000426318.1, ENST00000512681.5
      Conserved Domains (3) summary
      cd00191
      Location:218 → 282
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:102 → 221
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:101 → 208
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    9. NM_001430594.1 → NP_001417523.1  testican-3 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC010103, AC020599, AC023492, AC107210
      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000425502.1, ENST00000511269.5

    10. NM_016950.3 → NP_058646.2  testican-3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_058646.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC020599, AY358973
      Consensus CDS
      CCDS54817.1
      UniProtKB/Swiss-Prot
      B2R7M7, B3KR67, B4DGK5, B4DHB4, B4DHV3, B4DI46, B4DJY3, E7EP61, F5H099, O75705, Q6UW53, Q96Q26, Q9BQ16
      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000349677.3, ENST00000357154.7
      Conserved Domains (4) summary
      smart00280
      Location:140 → 183
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:316 → 380
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:200 → 319
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:199 → 306
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      166733384..167234945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008258.2 → XP_016863747.1  testican-3 isoform X3

      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000425570.1, ENST00000504953.5
      Conserved Domains (3) summary
      smart00280
      Location:137 → 180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:313 → 377
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16239
      Location:198 → 310
      EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)

    2. XM_011532018.2 → XP_011530320.1  testican-3 isoform X2

      See identical proteins and their annotated locations for XP_011530320.1

      UniProtKB/Swiss-Prot
      B2R7M7, B3KR67, B4DGK5, B4DHB4, B4DHV3, B4DI46, B4DJY3, E7EP61, F5H099, O75705, Q6UW53, Q96Q26, Q9BQ16
      UniProtKB/TrEMBL
      B4DFW5
      Related
      ENSP00000420920.1, ENST00000506886.5
      Conserved Domains (4) summary
      smart00280
      Location:140 → 183
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:316 → 380
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:200 → 319
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:199 → 306
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      170090608..170592260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350129.1 → XP_054206104.1  testican-3 isoform X3

      UniProtKB/TrEMBL
      B4DFW5

    2. XM_054350128.1 → XP_054206103.1  testican-3 isoform X2

      UniProtKB/Swiss-Prot
      B2R7M7, B3KR67, B4DGK5, B4DHB4, B4DHV3, B4DI46, B4DJY3, E7EP61, F5H099, O75705, Q6UW53, Q96Q26, Q9BQ16
      UniProtKB/TrEMBL
      B4DFW5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001204359.1: Suppressed sequence

      Description
      NM_001204359.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BQ16.2 GenPept UniProtKB/Swiss-Prot:Q9BQ16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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