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    SELENOS selenoprotein S [ Bos taurus (domestic cattle) ]

    Gene ID: 512276, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SELENOSprovided by VGNC
    Official Full Name
    selenoprotein Sprovided by VGNC
    Primary source
    VGNC:VGNC:57162
    See related
    Ensembl:ENSBTAG00000000640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SELS; VIMP
    Summary
    This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See SELENOS in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (5245019..5254197)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore-associated protein 2-like Neighboring gene uncharacterized LOC132343323 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene leucine rich repeat kinase 1 Neighboring gene microRNA mir-2362

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S. Bubenik JL, et al. PLoS One, 2013. PMID 23614019, Free PMC Article
    2. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
    3. Characterization of mammalian selenoproteomes. Kryukov GV, et al. Science, 2003 May 30. PMID 12775843
    4. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC137429

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of Derlin-1-VIMP complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    selenoprotein S
    Names
    VCP interacting membrane selenoprotein
    VCP-interacting membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046114.3 → NP_001039579.2  selenoprotein S isoform 1

      See identical proteins and their annotated locations for NP_001039579.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC112740, DV822816, EE934364
      UniProtKB/Swiss-Prot
      Q2KI76
      Related
      ENSBTAP00000000842.7, ENSBTAT00000000842.8
      Conserved Domains (1) summary
      pfam06936
      Location:1 → 188
      Selenoprotein_S; Selenoprotein S (SelS)

    2. NM_001348225.1 → NP_001335154.1  selenoprotein S isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      DN534347, EE243695, EV727840
      Conserved Domains (1) summary
      pfam06936
      Location:1 → 100
      Selenoprotein_S; Selenoprotein S (SelS)

    3. NM_001348226.1 → NP_001335155.1  selenoprotein S isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      BC112740, DT848352, EE934364, NKLS02000021
      UniProtKB/Swiss-Prot
      Q2KI76
      Conserved Domains (1) summary
      pfam06936
      Location:1 → 100
      Selenoprotein_S; Selenoprotein S (SelS)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5245019..5254197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KI76.2 GenPept UniProtKB/Swiss-Prot:Q2KI76

    Gene LinkOut

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