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    TAOK3 TAO kinase 3 [ Homo sapiens (human) ]

    Gene ID: 51347, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAOK3provided by HGNC
    Official Full Name
    TAO kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:18133
    See related
    Ensembl:ENSG00000135090 MIM:616711; AllianceGenome:HGNC:18133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPK; JIK; hKFC-A; MAP3K18
    Summary
    The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in brain (RPKM 12.0), prostate (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAOK3 in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118149801..118372907, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118137047..118360176, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118587606..118810712, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr12:118557876-118558588 and GRCh37_chr12:118558589-118559300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560014-118560725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560726-118561438 Neighboring gene Sharpr-MPRA regulatory region 10186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118564319-118564855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118573724-118574224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4923 Neighboring gene MPRA-validated peak1994 silencer Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7107 Neighboring gene Sharpr-MPRA regulatory region 13893 Neighboring gene NANOG hESC enhancer GRCh37_chr12:118666512-118667013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7109 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7110 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118778991-118779218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7111 Neighboring gene uncharacterized LOC124903031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118814415-118814915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7112 Neighboring gene SDS3 homolog, SIN3A corepressor complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate. Komazin-Meredith G, et al. Antiviral Res, 2015 Jul. PMID 25857706, Free PMC Article
    2. Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit. Gutteridge T, et al. J Pain Symptom Manage, 2018 Oct. PMID 30031856
    3. TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK. Ormonde JVS, et al. J Immunol, 2018 Dec 1. PMID 30373850
    4. Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway. Lai TC, et al. Cell Commun Signal, 2020 Oct 21. PMID 33087151, Free PMC Article
    5. STE20-type kinase TAOK3 regulates hepatic lipid partitioning. Xia Y, et al. Mol Metab, 2021 Dec. PMID 34634521, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
      Title: The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation.
    2. TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.
      Title: TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.
    3. The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.
      Title: The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.
    4. STE20-type kinase TAOK3 regulates hepatic lipid partitioning.
      Title: STE20-type kinase TAOK3 regulates hepatic lipid partitioning.
    5. Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-kappaB signaling pathway.
      Title: Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway.
    6. Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5alpha Promotes Cancer Invasion and Tumor Growth.
      Title: Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
    7. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
      Title: TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization.
    8. TAOK3 SNPs (rs1277441 and rs795484) were associated with opioid doses in advanced cancer patients receiving palliative care. The proportions of variant homozygotes (8.2% of patients) and their requirement for higher doses of opioids would appear potentially clinically important and should be validated in further studies.
      Title: Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit.
    9. TAOK3 is a positive regulator of TCR signaling by preventing premature SHP-1-mediated inactivation of LCK
      Title: TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK.
    10. Results show that three CpG loci within FYN were hypermethylated in obese individuals, while obesity was associated with lower methylation of CpG loci within PIWIL4 and TAOK3.
      Title: Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31808, DKFZp666H245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase TAO3
    Names
    CTCL-associated antigen HD-CL-09
    JNK/SAPK-inhibitory kinase
    STE20-like kinase
    cutaneous T-cell lymphoma-associated antigen HD-CL-09
    dendritic cell-derived protein kinase
    jun kinase-inhibitory kinase
    kinase from chicken homolog A
    thousand and one amino acid protein 3
    NP_001333416.1
    NP_001333417.1
    NP_001333418.1
    NP_001333419.1
    NP_001333420.1
    NP_001333421.1
    NP_001333422.1
    NP_001333423.1
    NP_001333424.1
    NP_001333425.1
    NP_001333426.1
    NP_057365.3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051835.1 RefSeqGene

      Range
      5039..228145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346487.2 → NP_001333416.1  serine/threonine-protein kinase TAO3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC026366, AC026367, AC073596
      UniProtKB/TrEMBL
      A8K0J3
      Conserved Domains (1) summary
      cd06633
      Location:2 → 314
      STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

    2. NM_001346488.2 → NP_001333417.1  serine/threonine-protein kinase TAO3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 4, encodes isoform b.
      Source sequence(s)
      AC026366, AC026367, AC073596
      Consensus CDS
      CCDS9188.1
      UniProtKB/Swiss-Prot
      Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
      UniProtKB/TrEMBL
      A8K0J3
      Conserved Domains (2) summary
      COG0419
      Location:454 → 874
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06633
      Location:2 → 314
      STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

    3. NM_001346489.2 → NP_001333418.1  serine/threonine-protein kinase TAO3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC026366, AF135158, DB165555
      Consensus CDS
      CCDS9188.1
      UniProtKB/Swiss-Prot
      Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
      UniProtKB/TrEMBL
      A8K0J3
      Related
      ENSP00000416374.2, ENST00000419821.6
      Conserved Domains (2) summary
      COG0419
      Location:454 → 874
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06633
      Location:2 → 314
      STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

    4. NM_001346490.2 → NP_001333419.1  serine/threonine-protein kinase TAO3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC026366, AC026367, AC073596
      UniProtKB/TrEMBL
      A8K0J3
      Conserved Domains (2) summary
      cl21453
      Location:1 → 144
      PKc_like; Protein Kinases, catalytic domain
      cl26511
      Location:254 → 720
      Neuromodulin_N; Gap junction protein N-terminal region

    5. NM_001346491.2 → NP_001333420.1  serine/threonine-protein kinase TAO3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
      Source sequence(s)
      AC026366, AC026367, AC073596
      UniProtKB/TrEMBL
      A8K0J3
      Conserved Domains (2) summary
      cl21453
      Location:1 → 144
      PKc_like; Protein Kinases, catalytic domain
      cl26511
      Location:245 → 711
      Neuromodulin_N; Gap junction protein N-terminal region

    6. NM_001346492.2 → NP_001333421.1  serine/threonine-protein kinase TAO3 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
      Source sequence(s)
      AC026366, AC026367, AC073596
      UniProtKB/TrEMBL
      A8K0J3
      Conserved Domains (2) summary
      cl21453
      Location:1 → 144
      PKc_like; Protein Kinases, catalytic domain
      cl26511
      Location:245 → 711
      Neuromodulin_N; Gap junction protein N-terminal region

    7. NM_001346493.2 → NP_001333422.1  serine/threonine-protein kinase TAO3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC026366, AC026367, AC073596

    8. NM_001346494.2 → NP_001333423.1  serine/threonine-protein kinase TAO3 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform f.
      Source sequence(s)
      AC026366
      Consensus CDS
      CCDS86334.1
      UniProtKB/TrEMBL
      B3KPH9, G3V1Q8
      Related
      ENSP00000443834.1, ENST00000537952.1
      Conserved Domains (2) summary
      PTZ00121
      Location:52 → 421
      PTZ00121; MAEBL; Provisional
      cl39057
      Location:310 → 410
      MS_channel; Mechanosensitive ion channel

    9. NM_001346495.2 → NP_001333424.1  serine/threonine-protein kinase TAO3 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform f.
      Source sequence(s)
      AC026366
      Consensus CDS
      CCDS86334.1
      UniProtKB/TrEMBL
      B3KPH9, G3V1Q8
      Conserved Domains (2) summary
      PTZ00121
      Location:52 → 421
      PTZ00121; MAEBL; Provisional
      cl39057
      Location:310 → 410
      MS_channel; Mechanosensitive ion channel

    10. NM_001346496.2 → NP_001333425.1  serine/threonine-protein kinase TAO3 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 12, encodes isoform g.
      Source sequence(s)
      AC026366
      UniProtKB/TrEMBL
      B3KPH9
      Conserved Domains (2) summary
      PTZ00121
      Location:7 → 387
      PTZ00121; MAEBL; Provisional
      cl39057
      Location:310 → 406
      MS_channel; Mechanosensitive ion channel

    11. NM_001346497.2 → NP_001333426.1  serine/threonine-protein kinase TAO3 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 11, encodes isoform g.
      Source sequence(s)
      AC026366
      UniProtKB/TrEMBL
      B3KPH9
      Conserved Domains (2) summary
      PTZ00121
      Location:7 → 387
      PTZ00121; MAEBL; Provisional
      cl39057
      Location:310 → 406
      MS_channel; Mechanosensitive ion channel

    12. NM_016281.4 → NP_057365.3  serine/threonine-protein kinase TAO3 isoform b

      See identical proteins and their annotated locations for NP_057365.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 3 and 4, encodes isoform b.
      Source sequence(s)
      AA744362, AI057643, AL833460, BC002756, DB066061
      Consensus CDS
      CCDS9188.1
      UniProtKB/Swiss-Prot
      Q658N1, Q8IUM4, Q9H2K8, Q9HC79, Q9NZM9, Q9UHG7
      UniProtKB/TrEMBL
      A8K0J3
      Related
      ENSP00000376317.3, ENST00000392533.8
      Conserved Domains (2) summary
      COG0419
      Location:454 → 874
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06633
      Location:2 → 314
      STKc_TAO3; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      118149801..118372907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      118137047..118360176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H2K8.2 GenPept UniProtKB/Swiss-Prot:Q9H2K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous