Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nus1provided by MGI
Official Full Name: NUS1 dehydrodolichyl diphosphate synthase subunitprovided by MGI
Primary source: MGI:MGI:1196365
See related: Ensembl:ENSMUSG00000023068 AllianceGenome:MGI:1196365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D10Ertd438e; 1600027K07Rik
Summary: Enables prenyltransferase activity. Acts upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 26.3), adrenal adult (RPKM 18.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 26.64 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (52293643..52316288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (52417547..52440192)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.
Title: Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.
Data demonstrate that NgBR is a unique receptor that promotes accumulation of prenylated Ras at the plasma membrane and promotes EGF pathways.
Title: The Nogo-B receptor promotes Ras plasma membrane localization and activation.
NgBR is critical for protein glycosylation during vascular development.
Title: NgBR is essential for endothelial cell glycosylation and vascular development.
Loss of Nogo-B receptor in mice causes early embryonic lethality and defects in glycosylation.
Title: Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation.
Our results indicate that the NgBR ectodomain is intrinsically unstructured without tertiary structures while the cytoplasmic domain is partially folded with secondary structures but without a tight tertiary packing [nogo-b receptor]
Title: Nogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domain.
identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B.
Title: Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

UniSTS:236351 (e-PCR)
- UniSTS:236351

AW538011 (e-PCR)
- UniSTS:180038

RH136533 (e-PCR)
- UniSTS:210515

D10Ertd438e (e-PCR), detects polymorphism
- UniSTS:167014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to dehydrodolichyl diphosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dehydrodolichyl diphosphate synthase activity	ISO Inferred from Sequence Orthology more info
enables dehydrodolichyl diphosphate synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prenyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to prenyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dolichol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dolichol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichyl diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichyl diphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein mannosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dehydrodolichyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dehydrodolichyl diphosphate synthase complex	ISO Inferred from Sequence Orthology more info
part_of dehydrodolichyl diphosphate synthase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dehydrodolichyl diphosphate synthase complex subunit Nus1

Names: Nogo-B receptor; dehydrodolichyl diphosphate syntase complex subunit Nus1; di-trans,poly-cis-decaprenylcistransferase; ngBR; nuclear undecaprenyl pyrophosphate synthase 1 homolog

NP_084526.1

EC 2.5.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030250.2 → NP_084526.1 dehydrodolichyl diphosphate synthase complex subunit Nus1

Status: VALIDATED

Source sequence(s)

AC153526

Consensus CDS

CCDS23841.1

UniProtKB/Swiss-Prot

Q0P6D7, Q3TIA3, Q3TIR7, Q3U1Z4, Q99LJ8

Related

ENSMUSP00000023830.9, ENSMUST00000023830.16

Conserved Domains (1) summary

COG0020
Location:124 → 297

UppS; Undecaprenyl pyrophosphate synthase [Lipid transport and metabolism]