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    Septin11 septin 11 [ Mus musculus (house mouse) ]

    Gene ID: 52398, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Septin11provided by MGI
    Official Full Name
    septin 11provided by MGI
    Primary source
    MGI:MGI:1277214
    See related
    Ensembl:ENSMUSG00000058013 AllianceGenome:MGI:1277214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sept11; D5Ertd606e; 6230410I01Rik
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis; protein localization; and regulation of synapse organization. Part of septin complex. Is expressed in brain; inner ear; and testis. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 19.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Septin11 in Genome Data Viewer
    Location:
    5 E2; 5 47.29 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (93227445..93329237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (93090995..93182368)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sosondowah ankyrin repeat domain family member B Neighboring gene predicted gene, 22915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93522357-93522466 Neighboring gene STARR-seq mESC enhancer starr_13664 Neighboring gene VISTA enhancer mm39 Neighboring gene cyclin I Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93635715-93635902 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lethal phenotype of mice carrying a Sept11 null mutation. Röseler S, et al. Biol Chem, 2011 Aug. PMID 21824005
    2. Physiological significance of WDR45, a responsible gene for β-propeller protein associated neurodegeneration (BPAN), in brain development. Noda M, et al. Sci Rep, 2021 Nov 19. PMID 34799629, Free PMC Article
    3. MUNC18-1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development. Hamada N, et al. Acta Neuropathol Commun, 2017 Nov 30. PMID 29191246, Free PMC Article
    4. Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Shinoda T, et al. Mol Biol Cell, 2010 Apr 15. PMID 20181826, Free PMC Article
    5. Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Ageta-Ishihara N, et al. Nat Commun, 2013. PMID 24113571, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization of symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009818.2 → NP_001009818.1  septin-11 isoform 3

      See identical proteins and their annotated locations for NP_001009818.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC134827, BC064466, CO042161
      Consensus CDS
      CCDS51549.1
      UniProtKB/TrEMBL
      A0A0J9YTY0
      Related
      ENSMUSP00000074293.8, ENSMUST00000074733.11
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    2. NM_001310669.1 → NP_001297598.1  septin-11 isoform 1

      See identical proteins and their annotated locations for NP_001297598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction in the 3' end compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is 1 aa shorter compared to isoform 4.
      Source sequence(s)
      AC134827, AK028475
      Consensus CDS
      CCDS80331.1
      UniProtKB/Swiss-Prot
      Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
      UniProtKB/TrEMBL
      A0A0J9YTY0
      Related
      ENSMUSP00000143928.2, ENSMUST00000201421.4
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    3. NM_001310671.1 → NP_001297600.1  septin-11 isoform 2

      See identical proteins and their annotated locations for NP_001297600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice site in the 3' coding region compared to variant 4. The resulting isoform (2) is shorter at the C-terminus compared to isoform 4.
      Source sequence(s)
      AC134827
      Consensus CDS
      CCDS80332.1
      UniProtKB/TrEMBL
      A0A0J9YTY0
      Related
      ENSMUSP00000144136.2, ENSMUST00000202308.4
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    4. NM_001347377.1 → NP_001334306.1  septin-11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC134827
      Consensus CDS
      CCDS84906.1
      UniProtKB/TrEMBL
      A0A0J9YTY0, A0A0J9YUL3
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      93227445..93329237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165288.1 → XP_036021181.1  septin-11 isoform X1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    2. XM_036165289.1 → XP_036021182.1  septin-11 isoform X1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    3. XM_006535098.5 → XP_006535161.1  septin-11 isoform X1

      See identical proteins and their annotated locations for XP_006535161.1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    4. XM_006535099.5 → XP_006535162.1  septin-11 isoform X1

      See identical proteins and their annotated locations for XP_006535162.1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    5. XM_006535100.5 → XP_006535163.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_006535163.1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    6. XM_006535101.5 → XP_006535164.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_006535164.1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    7. XM_006535103.5 → XP_006535166.1  septin-11 isoform X5

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    8. XM_011249531.4 → XP_011247833.1  septin-11 isoform X2

      See identical proteins and their annotated locations for XP_011247833.1

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    9. XM_017320978.3 → XP_017176467.1  septin-11 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    10. XM_011249532.4 → XP_011247834.1  septin-11 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:47 → 315
      CDC_Septin; CDC/Septin GTPase family

    11. XM_017320982.1 → XP_017176471.1  septin-11 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:1 → 249
      CDC_Septin; CDC/Septin GTPase family

    12. XM_017320980.3 → XP_017176469.1  septin-11 isoform X6

      UniProtKB/TrEMBL
      A0A0J9YTY0, A0A0J9YUL3
      Related
      ENSMUSP00000144235.2, ENSMUST00000202217.3
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    13. XM_030254690.2 → XP_030110550.1  septin-11 isoform X7

      UniProtKB/Swiss-Prot
      Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    14. XM_017320981.3 → XP_017176470.1  septin-11 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Related
      ENSMUSP00000143901.2, ENSMUST00000201700.4
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    15. XM_006535104.5 → XP_006535167.1  septin-11 isoform X6

      See identical proteins and their annotated locations for XP_006535167.1

      UniProtKB/TrEMBL
      A0A0J9YTY0, A0A0J9YUL3
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    16. XM_036165291.1 → XP_036021184.1  septin-11 isoform X7

      UniProtKB/Swiss-Prot
      Q3TBA0, Q3TC24, Q5D0F0, Q6P2K5, Q6P6I0, Q8C1B7
      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:38 → 306
      CDC_Septin; CDC/Septin GTPase family

    17. XM_006535108.4 → XP_006535171.1  septin-11 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:1 → 249
      CDC_Septin; CDC/Septin GTPase family

    18. XM_006535106.5 → XP_006535169.1  septin-11 isoform X8

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:36 → 304
      CDC_Septin; CDC/Septin GTPase family

    19. XM_030254691.1 → XP_030110551.1  septin-11 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:1 → 249
      CDC_Septin; CDC/Septin GTPase family

    20. XM_036165292.1 → XP_036021185.1  septin-11 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YTY0
      Conserved Domains (1) summary
      cd01850
      Location:1 → 249
      CDC_Septin; CDC/Septin GTPase family

    RNA

    1. XR_389284.5 RNA Sequence

    2. XR_001784719.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1B7.4 GenPept UniProtKB/Swiss-Prot:Q8C1B7

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