RecQ4 RecQ4 helicase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RecQ4provided by FlyBase
Official Full Name: RecQ4 helicaseprovided by FlyBase
Primary source: FLYBASE:FBgn0040290
Locus tag: Dmel_CG7487
See related: AllianceGenome:FB:FBgn0040290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg7487; CG7487; Dmel\CG7487; DmRECQ4; dRecQ4; RECQ4; RECQL4
Summary: Enables 3'-5' DNA helicase activity and single-stranded DNA binding activity. Involved in several processes, including DNA geometric change; DNA metabolic process; and positive regulation of G2/M transition of mitotic cell cycle. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including embryonic/larval optic lobe; embryonic/larval salivary gland; germinal proliferation center; germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in Baller-Gerold syndrome; Rothmund-Thomson syndrome; and rapadilino syndrome. Orthologous to human RECQL4 (RecQ like helicase 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66B10-66B10; 3-22 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8170640..8175978, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8163740..8169078, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recq4 is essential for viability.
Title: Drosophila RecQ4 has a 3'-5' DNA helicase activity that is essential for viability.
RecQ4 is required for most aspects of DNA replication during development.
Title: Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info
enables DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables four-way junction helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA rewinding	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in eggshell chorion gene amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RecQ4 helicase

Names: CG7487-PA; RecQ4-PA

NP_652607.1

EC 5.6.2.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8170640..8175978 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_144350.2 → NP_652607.1 RecQ4 helicase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652607.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NH11, Q9VSE6

Related

FBpp0076452

Conserved Domains (2) summary

COG0514
Location:864 → 1218

RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

cl26235
Location:9 → 55

RecQL4_SLD2_NTD; N-terminal homeodomain-like domain of metazoan RecQ protein-like 4 (RecQL4), fungal DNA replication regulator SLD2 and similar proteins