ACTR2 actin related protein 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ACTR2provided by VGNC
Official Full Name: actin related protein 2provided by VGNC
Primary source: VGNC:VGNC:25586
See related: BGD:BT17756; Ensembl:ENSBTAG00000009761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ARP2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (63594845..63632512)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structure of Arp2/3 complex
Title: Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites.
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation.
Title: Collapsin Response Mediator Protein-1 Regulates Arp2/3-dependent Actin Assembly.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
Title: Structural basis for regulation of Arp2/3 complex by GMF.
interacts with contactin and N-WASp
Title: Interaction of cortactin and N-WASp with Arp2/3 complex.
conserved surface residues to search for functionally important structural elements
Title: Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species.
crystal structures of Arp2/3 complex with bound ATP or ADP
Title: Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.
WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament.
Title: Conformational changes in the Arp2/3 complex leading to actin nucleation.
Data show that L. monocytogenes motility can be separated into an Arp2/3-dependent nucleation phase, and an Arp2/3-independent elongation phase which is dependent upon fascin.
Title: Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex.
domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an "actin-dimer" model for the active state
Title: Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_33882-33883:1054216033:1 (e-PCR)
- UniSTS:466813

MARC_33888-33889:1054216528:1 (e-PCR)
- UniSTS:466815

RH38846 (e-PCR)
- UniSTS:86995

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: actin-related protein 2

Names: ARP2 actin related protein 2 homolog; actin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.