Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2w1provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily w, polypeptide 1provided by MGI
Primary source: MGI:MGI:3616076
See related: Ensembl:ENSMUSG00000029541 AllianceGenome:MGI:3616076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm455
Summary: Predicted to enable several functions, including heme binding activity; retinoic acid 4-hydroxylase activity; and retinoid binding activity. Predicted to be involved in several processes, including aflatoxin metabolic process; phospholipid metabolic process; and retinoic acid catabolic process. Predicted to be located in cell surface and endoplasmic reticulum lumen. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in colon; large intestine; and small intestine. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 12.2), colon adult (RPKM 4.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 78.44 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (139338371..139345362)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (139352616..139359607)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show the developmental expression of CYP2W1 in the GI tract mediated by epigenetic modifications, its specific location, and regulation by anticancer drugs which can be considered as an adjuvant therapy of colon and hepatic cancers.
Title: Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans retinal binding	ISO Inferred from Sequence Orthology more info
enables all-trans retinal binding	ISS Inferred from Sequence or Structural Similarity more info
enables all-trans-retinol binding	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid 4-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aflatoxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aflatoxin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2W1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160265.2 → NP_001153737.1 cytochrome P450 2W1 precursor

See identical proteins and their annotated locations for NP_001153737.1

Status: VALIDATED

Source sequence(s)

AC161058

Consensus CDS

CCDS51683.1

UniProtKB/Swiss-Prot

E9Q816

Related

ENSMUSP00000031521.9, ENSMUST00000031521.13

Conserved Domains (1) summary

pfam00067
Location:35 → 489

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

139338371..139345362

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504719.2 → XP_006504782.1 cytochrome P450 2W1 isoform X1

Conserved Domains (1) summary

pfam00067
Location:35 → 455

p450; Cytochrome P450
XM_006504720.2 → XP_006504783.1 cytochrome P450 2W1 isoform X2

Conserved Domains (1) summary

pfam00067
Location:35 → 431

p450; Cytochrome P450
XM_006504722.2 → XP_006504785.1 cytochrome P450 2W1 isoform X4

Conserved Domains (1) summary

pfam00067
Location:35 → 384

p450; Cytochrome P450
XM_006504721.3 → XP_006504784.1 cytochrome P450 2W1 isoform X3

Conserved Domains (1) summary

pfam00067
Location:1 → 421

p450; Cytochrome P450