Ptprh protein tyrosine phosphatase receptor type H [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprhprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Hprovided by MGI
Primary source: MGI:MGI:3026877
See related: Ensembl:ENSMUSG00000035429 AllianceGenome:MGI:3026877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sap-1; R-PTP-H
Summary: Predicted to enable cadherin binding activity and protein tyrosine phosphatase activity. Involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Located in microvillus. Is expressed in intestine; stomach; and testis. Orthologous to human PTPRH (protein tyrosine phosphatase receptor type H). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 59.8), small intestine adult (RPKM 50.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.63 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4551607..4607040, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4548608..4604041, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study suggest the partial contribution of SAP-1 to the regulated transport of hydrophilic macromolecules through paracellular tight junctions.
Title: Microvillus-Specific Protein Tyrosine Phosphatase SAP-1 Plays a Role in Regulating the Intestinal Paracellular Transport of Macromolecules.
SAP-1 and CEACAM20 thus constitute a regulatory system through which the intestinal epithelium contributes to intestinal immunity.
Title: Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
These results thus suggest that SAP-1 is a microvillus-specific receptor-type protein tyrosine phosphatase that regulates intestinal tumorigenesis.
Title: SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

D1Mit491 (e-PCR), detects polymorphism
- UniSTS:128859

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase H

Names: receptor type protein tyrosine phosphatase sap-1; stomach cancer-associated protein tyrosine phosphatase 1

NP_997153.2

EC 3.1.3.48

XP_006540267.1

EC 3.1.3.48

XP_011248936.1

EC 3.1.3.48

XP_011248937.1

EC 3.1.3.48

XP_011248938.1

EC 3.1.3.48

XP_011248939.1

EC 3.1.3.48

XP_011248940.1

EC 3.1.3.48

XP_011248941.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207270.3 → NP_997153.2 receptor-type tyrosine-protein phosphatase H precursor

Status: VALIDATED

Source sequence(s)

AC161197, AC161218

Consensus CDS

CCDS51974.1

UniProtKB/Swiss-Prot

B6ZDS3, E9Q0N2, Q8BIW7

Related

ENSMUSP00000125833.2, ENSMUST00000166650.3

Conserved Domains (4) summary

smart00060
Location:156 → 234

FN3; Fibronectin type 3 domain

smart00194
Location:670 → 929

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:698 → 928

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4551607..4607040 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250634.3 → XP_011248936.1 receptor-type tyrosine-protein phosphatase H isoform X1

Conserved Domains (3) summary

smart00060
Location:334 → 412

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:881 → 1113

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006540204.4 → XP_006540267.1 receptor-type tyrosine-protein phosphatase H isoform X6

Conserved Domains (3) summary

smart00060
Location:518 → 594

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:788 → 1020

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250635.3 → XP_011248937.1 receptor-type tyrosine-protein phosphatase H isoform X2

Conserved Domains (3) summary

smart00060
Location:334 → 412

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:877 → 1109

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250639.3 → XP_011248941.1 receptor-type tyrosine-protein phosphatase H isoform X7

Conserved Domains (3) summary

smart00060
Location:334 → 412

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:788 → 1020

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250636.3 → XP_011248938.1 receptor-type tyrosine-protein phosphatase H isoform X3

Conserved Domains (3) summary

smart00060
Location:334 → 412

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:877 → 1109

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250638.3 → XP_011248940.1 receptor-type tyrosine-protein phosphatase H isoform X5

Conserved Domains (3) summary

smart00060
Location:334 → 412

FN3; Fibronectin type 3 domain

cd00063
Location:67 → 146

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:792 → 1024

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011250637.3 → XP_011248939.1 receptor-type tyrosine-protein phosphatase H isoform X4

Conserved Domains (3) summary

smart00060
Location:288 → 366

FN3; Fibronectin type 3 domain

cd00063
Location:21 → 100

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl28904
Location:835 → 1067

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily