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    SYTL2 synaptotagmin like 2 [ Homo sapiens (human) ]

    Gene ID: 54843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SYTL2provided by HGNC
    Official Full Name
    synaptotagmin like 2provided by HGNC
    Primary source
    HGNC:HGNC:15585
    See related
    Ensembl:ENSG00000137501 MIM:612880; AllianceGenome:HGNC:15585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151
    Summary
    The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
    Expression
    Broad expression in stomach (RPKM 22.4), colon (RPKM 16.3) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SYTL2 in Genome Data Viewer
    Location:
    11q14.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (85694229..85854870, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (85630917..85791555, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85405272..85565913, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85383205-85383705 Neighboring gene CREB/ATF bZIP transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396033-85396534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85396535-85397034 Neighboring gene coiled-coil domain containing 89 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:85472379-85473578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3822 Neighboring gene coiled-coil domain containing 83 Neighboring gene adenosylhomocysteinase pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:85646587-85647178 Neighboring gene solute carrier family 25 member 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Double C2 protein. A review. Duncan RR, et al. Biochimie, 2000 May. PMID 10865129
    2. [Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma]. Cao WF, et al. Zhonghua Bing Li Xue Za Zhi, 2010 May. PMID 20654157
    3. Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer. Sung HY, et al. Oncol Rep, 2016 Jul. PMID 27220283
    4. [Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion]. Cao WF, et al. Zhonghua Zhong Liu Za Zhi, 2010 Nov. PMID 21223688
    5. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Gálvez-Santisteban M, et al. Nat Cell Biol, 2012 Aug. PMID 22820376, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm.
      Title: Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm.
    2. SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
      Title: SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.
    3. Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2.
      Title: Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2.
    4. Overexpression of SYTL2 promoted metastatic potential.
      Title: Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.
    5. SLP2 may play an important role in tumorigenesis of esophageal squamous cell carcinoma.
      Title: [Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].
    6. A high expression level of SLP-2 may be associating with the development of invasion and metastasis in laryngeal squamous cell carcinoma and breast cancer.
      Title: [Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma].
    7. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
      Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
    8. Rab27a recruits Slp2a-hem on vesicular structures in peripheral CTLs and following CTL-target cell conjugate formation, the Slp2a-hem/Rab27a complex colocalizes with perforin-containing granules at the immunologic synapse
      Title: A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.
    9. Rab27A/Slp2a expression in limb girdle muscular dystrophy 2B muscle provides a compensatory vesicular trafficking pathway that is able to repair membrane damage in the absence of dysferlin.
      Title: Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.
    10. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
      Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Silencing of SLP2 by shRNA inhibits HIV-1 replication in Jurkat cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag SLP2 is a Rab27a effector required for HIV-1 Gag assembly at the plasma membrane in Jurkat cells PubMed
    gag Silencing the expression of SLP2 leads to a diffuse intracellular HIV-1 Gag staining pattern accompanied by a dramatic reduction in the association of Gag with the plasma membrane PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21219, FLJ34802, FLJ42764, FLJ45597, KIAA1597, MGC102768

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylserine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 2
    Names
    breast cancer-associated antigen SGA-72M
    chromosome 11 synaptotagmin
    exophilin-4
    protein phosphatase 1, regulatory subunit 151

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029712.3 RefSeqGene

      Range
      48729..165641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001162951.4 → NP_001156423.1  synaptotagmin-like protein 2 isoform g

      See identical proteins and their annotated locations for NP_001156423.1

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS53688.1
      UniProtKB/Swiss-Prot
      B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
      Conserved Domains (3) summary
      cd04020
      Location:769 → 925
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:629 → 756
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    2. NM_001162952.3 → NP_001156424.1  synaptotagmin-like protein 2 isoform h

      See identical proteins and their annotated locations for NP_001156424.1

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS53687.1
      Conserved Domains (2) summary
      cd04020
      Location:171 → 327
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:31 → 158
      C2; C2 domain

    3. NM_001162953.4 → NP_001156425.1  synaptotagmin-like protein 2 isoform i

      See identical proteins and their annotated locations for NP_001156425.1

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS53689.1
      UniProtKB/Swiss-Prot
      Q9HCH5
      Related
      ENSP00000318803.4, ENST00000316356.8
      Conserved Domains (3) summary
      cd04020
      Location:770 → 926
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:630 → 757
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    4. NM_001289608.2 → NP_001276537.1  synaptotagmin-like protein 2 isoform j

      See identical proteins and their annotated locations for NP_001276537.1

      Status: REVIEWED

      Source sequence(s)
      AK124754, AK296224, EU035829
      Consensus CDS
      CCDS76461.1
      UniProtKB/Swiss-Prot
      Q9HCH5
      Related
      ENSP00000434010.1, ENST00000527523.5
      Conserved Domains (2) summary
      cd04020
      Location:737 → 893
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:597 → 724
      C2; C2 domain

    5. NM_001289609.2 → NP_001276538.1  synaptotagmin-like protein 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AP000642
      UniProtKB/Swiss-Prot
      Q9HCH5
      Conserved Domains (2) summary
      cd04020
      Location:90 → 246
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:14 → 77
      C2; C2 domain

    6. NM_001289610.2 → NP_001276539.1  synaptotagmin-like protein 2 isoform h

      See identical proteins and their annotated locations for NP_001276539.1

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS53687.1
      Related
      ENSP00000432144.1, ENST00000533892.5
      Conserved Domains (2) summary
      cd04020
      Location:171 → 327
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:31 → 158
      C2; C2 domain

    7. NM_001365826.2 → NP_001352755.1  synaptotagmin-like protein 2 isoform l

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:746 → 902
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:606 → 733
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    8. NM_001365827.2 → NP_001352756.1  synaptotagmin-like protein 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:697 → 853
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:557 → 684
      C2; C2 domain

    9. NM_001365828.2 → NP_001352757.1  synaptotagmin-like protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS31652.1
      Related
      ENSP00000432996.1, ENST00000525702.5
      Conserved Domains (2) summary
      cd04020
      Location:211 → 367
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:71 → 198
      C2; C2 domain

    10. NM_001365829.2 → NP_001352758.1  synaptotagmin-like protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS31652.1
      Conserved Domains (2) summary
      cd04020
      Location:211 → 367
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:71 → 198
      C2; C2 domain

    11. NM_001365830.2 → NP_001352759.1  synaptotagmin-like protein 2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS31652.1
      Conserved Domains (2) summary
      cd04020
      Location:211 → 367
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:71 → 198
      C2; C2 domain

    12. NM_001365831.2 → NP_001352760.1  synaptotagmin-like protein 2 isoform n

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Conserved Domains (2) summary
      cd04020
      Location:160 → 316
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:20 → 147
      C2; C2 domain

    13. NM_001365832.2 → NP_001352761.1  synaptotagmin-like protein 2 isoform o

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Conserved Domains (2) summary
      cd04020
      Location:103 → 259
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:20 → 92
      C2; C2 domain

    14. NM_001365833.2 → NP_001352762.1  synaptotagmin-like protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS41698.1
      Conserved Domains (2) summary
      cd04020
      Location:200 → 356
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:60 → 187
      C2; C2 domain

    15. NM_001365834.2 → NP_001352763.1  synaptotagmin-like protein 2 isoform p

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Conserved Domains (2) summary
      cd04020
      Location:143 → 299
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:60 → 132
      C2; C2 domain

    16. NM_001365835.2 → NP_001352764.1  synaptotagmin-like protein 2 isoform q

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Conserved Domains (2) summary
      cd04020
      Location:264 → 420
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:124 → 251
      C2; C2 domain

    17. NM_001394447.1 → NP_001381376.1  synaptotagmin-like protein 2 isoform r

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:2073 → 2229
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1933 → 2060
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    18. NM_001394448.1 → NP_001381377.1  synaptotagmin-like protein 2 isoform s

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS91568.1
      UniProtKB/TrEMBL
      A0A0U1RR07
      Related
      ENSP00000489269.1, ENST00000634661.1
      Conserved Domains (3) summary
      cd04020
      Location:2058 → 2214
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1918 → 2045
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    19. NM_001394449.1 → NP_001381378.1  synaptotagmin-like protein 2 isoform s

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS91568.1
      UniProtKB/TrEMBL
      A0A0U1RR07
      Conserved Domains (3) summary
      cd04020
      Location:2058 → 2214
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1918 → 2045
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    20. NM_001394450.1 → NP_001381379.1  synaptotagmin-like protein 2 isoform t

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:2031 → 2187
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1891 → 2018
      C2; C2 domain

    21. NM_001394451.1 → NP_001381380.1  synaptotagmin-like protein 2 isoform u

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:2030 → 2186
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1890 → 2017
      C2; C2 domain

    22. NM_001394452.1 → NP_001381381.1  synaptotagmin-like protein 2 isoform v

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (1) summary
      cd04020
      Location:1870 → 2026
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4

    23. NM_001394453.1 → NP_001381382.1  synaptotagmin-like protein 2 isoform w

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:786 → 942
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:646 → 773
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    24. NM_001394454.1 → NP_001381383.1  synaptotagmin-like protein 2 isoform w

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:786 → 942
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:646 → 773
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    25. NM_001394455.1 → NP_001381384.1  synaptotagmin-like protein 2 isoform x

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:785 → 941
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:645 → 772
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    26. NM_001394456.1 → NP_001381385.1  synaptotagmin-like protein 2 isoform x

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:785 → 941
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:645 → 772
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    27. NM_001394457.1 → NP_001381386.1  synaptotagmin-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS53688.1
      UniProtKB/Swiss-Prot
      B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
      Conserved Domains (3) summary
      cd04020
      Location:769 → 925
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:629 → 756
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    28. NM_001394458.1 → NP_001381387.1  synaptotagmin-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS53688.1
      UniProtKB/Swiss-Prot
      B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
      Conserved Domains (3) summary
      cd04020
      Location:769 → 925
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:629 → 756
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    29. NM_001394459.1 → NP_001381388.1  synaptotagmin-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS53688.1
      UniProtKB/Swiss-Prot
      B3KRS3, B4DJT5, B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, Q8ND34, Q96BJ2, Q9H768, Q9HCH5, Q9NXM1
      Related
      ENSP00000431701.1, ENST00000528231.5
      Conserved Domains (3) summary
      cd04020
      Location:769 → 925
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:629 → 756
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    30. NM_001394460.1 → NP_001381389.1  synaptotagmin-like protein 2 isoform y

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:759 → 915
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:619 → 746
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    31. NM_001394461.1 → NP_001381390.1  synaptotagmin-like protein 2 isoform z

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:758 → 914
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:618 → 745
      C2; C2 domain

    32. NM_001394462.1 → NP_001381391.1  synaptotagmin-like protein 2 isoform aa

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:743 → 899
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:603 → 730
      C2; C2 domain

    33. NM_001394464.1 → NP_001381393.1  synaptotagmin-like protein 2 isoform bb

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:742 → 898
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:602 → 729
      C2; C2 domain

    34. NM_001394465.1 → NP_001381394.1  synaptotagmin-like protein 2 isoform cc

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:728 → 884
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:645 → 717
      C2; C2 domain

    35. NM_001394466.1 → NP_001381395.1  synaptotagmin-like protein 2 isoform dd

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:721 → 877
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:581 → 708
      C2; C2 domain

    36. NM_001394467.1 → NP_001381396.1  synaptotagmin-like protein 2 isoform ee

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:719 → 875
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:579 → 706
      C2; C2 domain

    37. NM_001394468.1 → NP_001381397.1  synaptotagmin-like protein 2 isoform ff

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:718 → 874
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:578 → 705
      C2; C2 domain

    38. NM_001394469.1 → NP_001381398.1  synaptotagmin-like protein 2 isoform gg

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:711 → 867
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:571 → 698
      C2; C2 domain

    39. NM_001394470.1 → NP_001381399.1  synaptotagmin-like protein 2 isoform hh

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:704 → 860
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:586 → 691
      C2; C2 domain

    40. NM_001394471.1 → NP_001381400.1  synaptotagmin-like protein 2 isoform ii

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:686 → 842
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:603 → 675
      C2; C2 domain

    41. NM_001394472.1 → NP_001381401.1  synaptotagmin-like protein 2 isoform ii

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (2) summary
      cd04020
      Location:686 → 842
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:603 → 675
      C2; C2 domain

    42. NM_001394473.1 → NP_001381402.1  synaptotagmin-like protein 2 isoform jj

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:2047 → 2203
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1907 → 2034
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    43. NM_032943.5 → NP_116561.1  synaptotagmin-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_116561.1

      Status: REVIEWED

      Source sequence(s)
      AB046817, AK124754, DC348081, EU035829
      Consensus CDS
      CCDS31649.1
      UniProtKB/Swiss-Prot
      Q9HCH5
      Related
      ENSP00000374610.4, ENST00000389960.8
      Conserved Domains (3) summary
      cd04020
      Location:745 → 901
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:605 → 732
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    44. NM_206927.4 → NP_996810.2  synaptotagmin-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Consensus CDS
      CCDS91569.1
      UniProtKB/TrEMBL
      A0A8J9FM55
      Related
      ENSP00000352065.7, ENST00000359152.10
      Conserved Domains (3) summary
      cd04020
      Location:2074 → 2230
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1934 → 2061
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    45. NM_206928.4 → NP_996811.2  synaptotagmin-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AP000642, AP000974
      Conserved Domains (3) summary
      cd04020
      Location:2057 → 2213
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:1917 → 2044
      C2; C2 domain
      cl22851
      Location:5 → 41
      PHD_SF; PHD finger superfamily

    46. NM_206929.4 → NP_996812.1  synaptotagmin-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_996812.1

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS31652.1
      Related
      ENSP00000435855.1, ENST00000529581.5
      Conserved Domains (2) summary
      cd04020
      Location:211 → 367
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:71 → 198
      C2; C2 domain

    47. NM_206930.4 → NP_996813.1  synaptotagmin-like protein 2 isoform f

      See identical proteins and their annotated locations for NP_996813.1

      Status: REVIEWED

      Source sequence(s)
      AP000642
      Consensus CDS
      CCDS41698.1
      Related
      ENSP00000374608.3, ENST00000389958.7
      Conserved Domains (2) summary
      cd04020
      Location:200 → 356
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:60 → 187
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      85694229..85854870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427166.1 → XP_047283122.1  synaptotagmin-like protein 2 isoform X14

    2. XM_047427162.1 → XP_047283118.1  synaptotagmin-like protein 2 isoform X10

    3. XM_047427158.1 → XP_047283114.1  synaptotagmin-like protein 2 isoform X6

    4. XM_047427174.1 → XP_047283130.1  synaptotagmin-like protein 2 isoform X22

    5. XM_047427168.1 → XP_047283124.1  synaptotagmin-like protein 2 isoform X16

    6. XM_017017934.2 → XP_016873423.1  synaptotagmin-like protein 2 isoform X1

    7. XM_047427171.1 → XP_047283127.1  synaptotagmin-like protein 2 isoform X19

    8. XM_047427173.1 → XP_047283129.1  synaptotagmin-like protein 2 isoform X21

    9. XM_047427161.1 → XP_047283117.1  synaptotagmin-like protein 2 isoform X9

    10. XM_047427175.1 → XP_047283131.1  synaptotagmin-like protein 2 isoform X23

    11. XM_047427167.1 → XP_047283123.1  synaptotagmin-like protein 2 isoform X15

    12. XM_047427164.1 → XP_047283120.1  synaptotagmin-like protein 2 isoform X12

    13. XM_047427170.1 → XP_047283126.1  synaptotagmin-like protein 2 isoform X18

    14. XM_047427156.1 → XP_047283112.1  synaptotagmin-like protein 2 isoform X4

    15. XM_047427155.1 → XP_047283111.1  synaptotagmin-like protein 2 isoform X3

    16. XM_047427163.1 → XP_047283119.1  synaptotagmin-like protein 2 isoform X11

    17. XM_047427169.1 → XP_047283125.1  synaptotagmin-like protein 2 isoform X17

    18. XM_047427172.1 → XP_047283128.1  synaptotagmin-like protein 2 isoform X20

    19. XM_047427165.1 → XP_047283121.1  synaptotagmin-like protein 2 isoform X13

    20. XM_047427153.1 → XP_047283109.1  synaptotagmin-like protein 2 isoform X2

    21. XM_047427157.1 → XP_047283113.1  synaptotagmin-like protein 2 isoform X5

    22. XM_047427176.1 → XP_047283132.1  synaptotagmin-like protein 2 isoform X25

    23. XM_017017939.2 → XP_016873428.1  synaptotagmin-like protein 2 isoform X24

    24. XM_011545116.3 → XP_011543418.1  synaptotagmin-like protein 2 isoform X26

      See identical proteins and their annotated locations for XP_011543418.1

      Conserved Domains (2) summary
      cd04020
      Location:160 → 316
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:20 → 147
      C2; C2 domain

    25. XM_047427159.1 → XP_047283115.1  synaptotagmin-like protein 2 isoform X7

    26. XM_047427160.1 → XP_047283116.1  synaptotagmin-like protein 2 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      85630917..85791555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369194.1 → XP_054225169.1  synaptotagmin-like protein 2 isoform X28

    2. XM_054369197.1 → XP_054225172.1  synaptotagmin-like protein 2 isoform X6

    3. XM_054369193.1 → XP_054225168.1  synaptotagmin-like protein 2 isoform X27

    4. XM_054369211.1 → XP_054225186.1  synaptotagmin-like protein 2 isoform X22

    5. XM_054369205.1 → XP_054225180.1  synaptotagmin-like protein 2 isoform X16

    6. XM_054369190.1 → XP_054225165.1  synaptotagmin-like protein 2 isoform X1

    7. XM_054369208.1 → XP_054225183.1  synaptotagmin-like protein 2 isoform X19

    8. XM_054369210.1 → XP_054225185.1  synaptotagmin-like protein 2 isoform X21

    9. XM_054369200.1 → XP_054225175.1  synaptotagmin-like protein 2 isoform X9

    10. XM_054369212.1 → XP_054225187.1  synaptotagmin-like protein 2 isoform X23

    11. XM_054369204.1 → XP_054225179.1  synaptotagmin-like protein 2 isoform X15

    12. XM_054369202.1 → XP_054225177.1  synaptotagmin-like protein 2 isoform X12

    13. XM_054369207.1 → XP_054225182.1  synaptotagmin-like protein 2 isoform X18

    14. XM_054369195.1 → XP_054225170.1  synaptotagmin-like protein 2 isoform X4

    15. XM_054369192.1 → XP_054225167.1  synaptotagmin-like protein 2 isoform X3

    16. XM_054369201.1 → XP_054225176.1  synaptotagmin-like protein 2 isoform X11

    17. XM_054369206.1 → XP_054225181.1  synaptotagmin-like protein 2 isoform X17

    18. XM_054369209.1 → XP_054225184.1  synaptotagmin-like protein 2 isoform X20

    19. XM_054369203.1 → XP_054225178.1  synaptotagmin-like protein 2 isoform X13

    20. XM_054369191.1 → XP_054225166.1  synaptotagmin-like protein 2 isoform X2

    21. XM_054369196.1 → XP_054225171.1  synaptotagmin-like protein 2 isoform X5

    22. XM_054369214.1 → XP_054225189.1  synaptotagmin-like protein 2 isoform X25

    23. XM_054369213.1 → XP_054225188.1  synaptotagmin-like protein 2 isoform X24

    24. XM_054369215.1 → XP_054225190.1  synaptotagmin-like protein 2 isoform X26

    25. XM_054369198.1 → XP_054225173.1  synaptotagmin-like protein 2 isoform X7

    26. XM_054369199.1 → XP_054225174.1  synaptotagmin-like protein 2 isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017695.1: Suppressed sequence

      Description
      NM_017695.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NM_032379.3: Suppressed sequence

      Description
      NM_032379.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCH5.3 GenPept UniProtKB/Swiss-Prot:Q9HCH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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