PPP2CA protein phosphatase 2 catalytic subunit alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP2CAprovided by HGNC
Official Full Name: protein phosphatase 2 catalytic subunit alphaprovided by HGNC
Primary source: HGNC:HGNC:9299
See related: Ensembl:ENSG00000113575 MIM:176915; AllianceGenome:HGNC:9299
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HJS3; RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (134194332..134226073, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (134717969..134749722, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (133530023..133561764, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drug-resistant exosome miR-99b-3p induces macrophage polarization and confers chemoresistance on sensitive cells by targeting PPP2CA.
Title: Drug-resistant exosome miR-99b-3p induces macrophage polarization and confers chemoresistance on sensitive cells by targeting PPP2CA.
PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer.
Title: PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer.
PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma.
Title: PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma.
The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors.
Title: The Pivotal Role of Protein Phosphatase 2A (PP2A) in Brain Tumors.
Liver PP2A-Calpha Protects From Parenteral Nutrition-associated Hepatic Steatosis.
Title: Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis.
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
Title: The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells.
PP2A Catalytic Subunit alpha promotes fibroblast activation and kidney fibrosis via ERK pathway.
Title: PP2A Catalytic Subunit α promotes fibroblast activation and kidney fibrosis via ERK pathway.
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
Title: Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
Title: Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.
Title: Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation.

Submit: New GeneRIF Correction See all GeneRIFs (152)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Houge-Janssens syndrome 3 MedGen: C5193048 OMIM: 618354 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of PPP2CA is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed
	tat	HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly	PubMed
	tat	An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression	PubMed
Vpr	vpr	Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain	PubMed
	vpr	HIV-1 Vpr was found to upregulate PP2A in fission yeast	PubMed
	vpr	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed
Vpu	vpu	IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism	PubMed
nucleocapsid	gag	HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN74323 (e-PCR)
- UniSTS:399123

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526870

Ppp2ca (e-PCR), detects polymorphism
- UniSTS:526871

PMC22838P1 (e-PCR)
- UniSTS:272153

WI-18935 (e-PCR)
- UniSTS:22638

PPP2CA_3845 (e-PCR)
- UniSTS:462448

RH68282 (e-PCR)
- UniSTS:71536

D5S2601 (e-PCR)
- UniSTS:59547

D5S2601 (e-PCR)
- UniSTS:59548

PPP2CA (e-PCR)
- UniSTS:278947

D5S2786 (e-PCR)
- UniSTS:473854

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GABA receptor binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables tau protein binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glycolytic process through fructose-6-phosphate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-threonine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of growth	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to lead ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lead ion	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	TAS Traceable Author Statement more info	PubMed
part_of protein serine/threonine phosphatase complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Names: PP2A-alpha; protein phosphatase 2, catalytic subunit, alpha isozyme; replication protein C

NP_001341948.1

EC 3.1.3.16

NP_002706.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_046997.2 RefSeqGene

Range

5000..36741

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001355019.2 → NP_001341948.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC104109

Consensus CDS

CCDS93781.1

UniProtKB/TrEMBL

A0A8V8TQA1, B3KQ51, E5RHP4

Related

ENSP00000515257.1, ENST00000703311.1

Conserved Domains (1) summary

cd07415
Location:1 → 228

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
NM_002715.4 → NP_002706.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

See identical proteins and their annotated locations for NP_002706.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC104109, AK097599

Consensus CDS

CCDS4173.1

UniProtKB/Swiss-Prot

P05323, P13197, P67775

UniProtKB/TrEMBL

B3KUN1, Q6I9T8

Related

ENSP00000418447.1, ENST00000481195.6

Conserved Domains (1) summary

cd07415
Location:9 → 293

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RNA

NR_149151.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' end and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC104109