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    ZNF821 zinc finger protein 821 [ Homo sapiens (human) ]

    Gene ID: 55565, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF821provided by HGNC
    Official Full Name
    zinc finger protein 821provided by HGNC
    Primary source
    HGNC:HGNC:28043
    See related
    Ensembl:ENSG00000102984 AllianceGenome:HGNC:28043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Broad expression in testis (RPKM 7.7), brain (RPKM 2.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF821 in Genome Data Viewer
    Location:
    16q22.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (71859680..71895256, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77676829..77701807, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71893583..71918559, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 13 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11080 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71878951-71879723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71879724-71880495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:71884603-71885382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11084 Neighboring gene ataxin 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:71918951-71919451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:71929209-71929774 Neighboring gene IST1 factor associated with ESCRT-III Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:71971508-71972085 Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene ribosomal protein L39 pseudogene 31 Neighboring gene ATP synthase F1 subunit alpha pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STPR, a 23-amino acid tandem repeat domain, found in the human function-unknown protein ZNF821. Nonaka Y, et al. Biochemistry, 2010 Sep 28. PMID 20795678
    2. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
    3. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
    4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
    5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 821

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201552.2 → NP_001188481.1  zinc finger protein 821 isoform 1

      See identical proteins and their annotated locations for NP_001188481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK296603, AK313693, BC004563, DA324992
      Consensus CDS
      CCDS56006.1
      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Related
      ENSP00000398089.1, ENST00000425432.6
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001201553.1 → NP_001188482.1  zinc finger protein 821 isoform 1

      See identical proteins and their annotated locations for NP_001188482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC009127, AK296603, BC004563
      Consensus CDS
      CCDS56006.1
      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Related
      ENSP00000455648.1, ENST00000565601.5
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001201554.1 → NP_001188483.1  zinc finger protein 821 isoform 2

      See identical proteins and their annotated locations for NP_001188483.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      BC004563, BC012116, BC091492, DA324992
      Consensus CDS
      CCDS32481.1
      UniProtKB/TrEMBL
      A0A0C4DH12, H3BS68
      Related
      ENSP00000313822.6, ENST00000313565.10
      Conserved Domains (2) summary
      TIGR01642
      Location:233 → 345
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001201556.1 → NP_001188485.1  zinc finger protein 821 isoform 3

      See identical proteins and their annotated locations for NP_001188485.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK296603, AK313693, AL538838, BC004563, BC091492, DA324992
      Consensus CDS
      CCDS73911.1
      UniProtKB/TrEMBL
      A0A087WXX1, H3BQE4
      Related
      ENSP00000481362.1, ENST00000611294.4

    5. NM_001318238.2 → NP_001305167.1  zinc finger protein 821 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
      Source sequence(s)
      AC009127, BC004563, BC091492
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001318239.2 → NP_001305168.1  zinc finger protein 821 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (4), which is shorter than isoform 1.
      Source sequence(s)
      BC091492
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001376297.1 → NP_001363226.1  zinc finger protein 821 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009127, AC010653
      Consensus CDS
      CCDS56006.1
      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    8. NM_001376298.1 → NP_001363227.1  zinc finger protein 821 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009127, AC010653
      Consensus CDS
      CCDS56006.1
      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Related
      ENSP00000456563.1, ENST00000568666.5
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    9. NM_001376299.1 → NP_001363228.1  zinc finger protein 821 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC009127, AC010653
      Consensus CDS
      CCDS56006.1
      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    10. NM_001376300.1 → NP_001363229.1  zinc finger protein 821 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009127, AC010653
      Consensus CDS
      CCDS32481.1
      UniProtKB/TrEMBL
      A0A0C4DH12, H3BS68
      Conserved Domains (2) summary
      TIGR01642
      Location:233 → 345
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_017530.2 → NP_060000.1  zinc finger protein 821 isoform 2

      See identical proteins and their annotated locations for NP_060000.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      AF070588, AK296603, BC004563
      Consensus CDS
      CCDS32481.1
      UniProtKB/TrEMBL
      A0A0C4DH12, H3BS68
      Related
      ENSP00000405908.2, ENST00000446827.6
      Conserved Domains (2) summary
      TIGR01642
      Location:233 → 345
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      71859680..71895256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434342.1 → XP_047290298.1  zinc finger protein 821 isoform X1

      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541

    2. XM_047434347.1 → XP_047290303.1  zinc finger protein 821 isoform X3

    3. XM_011523212.4 → XP_011521514.1  zinc finger protein 821 isoform X2

      Conserved Domains (2) summary
      PHA02586
      Location:294 → 355
      68; prohead core protein; Provisional
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_047434343.1 → XP_047290299.1  zinc finger protein 821 isoform X3

    5. XM_011523214.3 → XP_011521516.1  zinc finger protein 821 isoform X3

      See identical proteins and their annotated locations for XP_011521516.1

      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_047434346.1 → XP_047290302.1  zinc finger protein 821 isoform X3

    7. XM_011523211.4 → XP_011521513.1  zinc finger protein 821 isoform X1

      See identical proteins and their annotated locations for XP_011521513.1

      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541
      UniProtKB/TrEMBL
      H3BS68
      Conserved Domains (3) summary
      TIGR01642
      Location:275 → 387
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:150 → 172
      zf-C2H2; Zinc finger, C2H2 type

    8. XM_047434345.1 → XP_047290301.1  zinc finger protein 821 isoform X3

    9. XM_047434344.1 → XP_047290300.1  zinc finger protein 821 isoform X3

    10. XM_017023422.2 → XP_016878911.1  zinc finger protein 821 isoform X3

      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      77676829..77701807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313429.1 → XP_054169404.1  zinc finger protein 821 isoform X3

    2. XM_054313422.1 → XP_054169397.1  zinc finger protein 821 isoform X2

    3. XM_054313424.1 → XP_054169399.1  zinc finger protein 821 isoform X3

    4. XM_054313423.1 → XP_054169398.1  zinc finger protein 821 isoform X3

    5. XM_054313428.1 → XP_054169403.1  zinc finger protein 821 isoform X3

    6. XM_054313421.1 → XP_054169396.1  zinc finger protein 821 isoform X1

      UniProtKB/Swiss-Prot
      A6NK48, B4DKK4, D3DWS3, O75541

    7. XM_054313427.1 → XP_054169402.1  zinc finger protein 821 isoform X3

    8. XM_054313425.1 → XP_054169400.1  zinc finger protein 821 isoform X3

    9. XM_054313426.1 → XP_054169401.1  zinc finger protein 821 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75541.3 GenPept UniProtKB/Swiss-Prot:O75541

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