Tspan6 tetraspanin 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan6provided by MGI
Official Full Name: tetraspanin 6provided by MGI
Primary source: MGI:MGI:1926264
See related: Ensembl:ENSMUSG00000067377 AllianceGenome:MGI:1926264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T245; Tm4sf; Tm4sf6; TSPAN-6; 6720473L21Rik
Summary: Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction and negative regulation of cytoplasmic pattern recognition receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in 1st branchial arch; jaw; and pancreas epithelium. Orthologous to human TSPAN6 (tetraspanin 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 40.5), whole brain E14.5 (RPKM 35.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: X E3; X 55.47 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (132791817..132801957, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (133891068..133901208, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results shows that TSPAN6 is a crucial player in Amyloid Precursor Protein-C-terminal fragment turnover
Title: Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.
Tspan6 KO mice show normal locomotor behaviour and no defects in hippocampus-dependent memory tests.
Title: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr1b (e-PCR), detects polymorphism
- UniSTS:143414

RH136113 (e-PCR)
- UniSTS:210108

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tetraspanin-6

Names: tetraspan TM4SF; transmembrane 4 superfamily member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019656.3 → NP_062630.2 tetraspanin-6

See identical proteins and their annotated locations for NP_062630.2

Status: VALIDATED

Source sequence(s)

AA458002, AK167384, AV351536

Consensus CDS

CCDS30387.1

UniProtKB/Swiss-Prot

O70401

UniProtKB/TrEMBL

Q3TV84, Q99L96

Related

ENSMUSP00000084838.6, ENSMUST00000087557.12

Conserved Domains (1) summary

pfam00335
Location:17 → 233

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

132791817..132801957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251428.1 → XP_030107288.1 tetraspanin-6 isoform X1

UniProtKB/Swiss-Prot

O70401

UniProtKB/TrEMBL

Q3TV84, Q99L96

Conserved Domains (1) summary

pfam00335
Location:17 → 233

Tetraspannin; Tetraspanin family
XM_036162050.1 → XP_036017943.1 tetraspanin-6 isoform X2

Conserved Domains (1) summary

cd03161
Location:24 → 121

TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...