Ctsr cathepsin R [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctsrprovided by MGI
Official Full Name: cathepsin Rprovided by MGI
Primary source: MGI:MGI:1861723
See related: Ensembl:ENSMUSG00000055679 AllianceGenome:MGI:1861723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in brain; extraembryonic component; head; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward placenta adult (RPKM 141.9) See more
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Genomic context

Location:: 13 B2; 13 32.67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61307029..61312002, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (61159215..61164188, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice.
Title: Cathepsin gene expression in mouse placenta during the latter half of pregnancy.
chromosome mapping of this enzyme in mouse placenta.
Title: Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization.

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General gene information

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Markers

mHAa31g11.seq (e-PCR)
- UniSTS:125977

AI428350 (e-PCR)
- UniSTS:180548

Ctsr (e-PCR), detects polymorphism
- UniSTS:256972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein catabolic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: cathepsin R

Names: lysosomal cysteine protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020284.1 → NP_064680.1 cathepsin R precursor

Status: PROVISIONAL

Source sequence(s)

AF245399

Consensus CDS

CCDS26585.1

UniProtKB/Swiss-Prot

Q9JIA9

UniProtKB/TrEMBL

Q497X4, Q58IU7

Related

ENSMUSP00000021889.5, ENSMUST00000021889.6

Conserved Domains (3) summary

PTZ00203
Location:15 → 332

PTZ00203; cathepsin L protease; Provisional

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:116 → 332

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...