dcc DCC netrin 1 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dccprovided by ZNC
Official Full Name: DCC netrin 1 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011101-2
See related: Ensembl:ENSDARG00000104282 AllianceGenome:ZFIN:ZDB-GENE-011101-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zdcc
Summary: Enables netrin receptor activity involved in chemoattraction. Acts upstream of or within with a positive effect on commissural neuron axon guidance. Acts upstream of or within neuron differentiation and regulation of axon extension. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (31747..201600, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (3336..102122, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc.
Title: Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc.
Pioneer Axons Utilize a Dcc Signaling-Mediated Invasion Brake to Precisely Complete Their Pathfinding Odyssey.
Title: Pioneer Axons Utilize a Dcc Signaling-Mediated Invasion Brake to Precisely Complete Their Pathfinding Odyssey.
Schwann cell and dcc-mediated guidance are critical early during regeneration to direct growth cones across the transection gap and onto their original axonal trajectory.
Title: Schwann cells and deleted in colorectal carcinoma direct regenerating motor axons towards their original path.
in dcc mutants, turns on the inappropriate side of the body are caused by aberrant ipsilateral axonal projections
Title: Mirror movement-like defects in startle behavior of zebrafish dcc mutants are caused by aberrant midline guidance of identified descending hindbrain neurons.
Dcc-Netrin1 and roundabout2 (Robo2)-Slit coordinate axonal projection choices of neurons in the developing forebrain.
Title: Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts.
Dcc regulates polarized axon initiation and asymmetric outgrowth of forebrain neurons
Title: Dcc regulates asymmetric outgrowth of forebrain neurons in zebrafish.
First evidence that Netrin/DCC axon guidance molecules act in dendrites in a vertebrate system.
Title: Netrin/DCC signaling controls contralateral dendrites of octavolateralis efferent neurons.
dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well
Title: Cloning of full-length zebrafish dcc and expression analysis during embryonic and early larval development.

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General gene information

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Markers

G40483 (e-PCR)
- UniSTS:68675

z1492 (e-PCR), detects polymorphism
- UniSTS:238235

z6916 (e-PCR), detects polymorphism
- UniSTS:205271

G45410 (e-PCR)
- UniSTS:106212

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables netrin receptor activity involved in chemoattraction	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within olfactory bulb axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory bulb axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin receptor DCC

Names: deleted in colorectal cancer; deleted in colorectal carcinoma; spaced out; spo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034985.1 → NP_001030157.1 netrin receptor DCC precursor

See identical proteins and their annotated locations for NP_001030157.1

Status: PROVISIONAL

Source sequence(s)

AY956314

UniProtKB/TrEMBL

Q49BB0

Related

ENSDARP00000137236.2, ENSDART00000158495.2

Conserved Domains (5) summary

smart00410
Location:142 → 226

IG_like; Immunoglobulin like

cd00063
Location:425 → 517

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:327 → 412

I-set; Immunoglobulin I-set domain

pfam06583
Location:1125 → 1419

Neogenin_C; Neogenin C-terminus

cl11960
Location:36 → 131

Ig; Immunoglobulin domain