Slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc15a2provided by MGI
Official Full Name: solute carrier family 15 (H+/peptide transporter), member 2provided by MGI
Primary source: MGI:MGI:1890457
See related: Ensembl:ENSMUSG00000022899 AllianceGenome:MGI:1890457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pept2; 8430408C16Rik
Summary: Enables dipeptide transmembrane transporter activity and high-affinity oligopeptide transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and regulation of nucleotide-binding activity domain, leucine rich repeat containing receptor signaling pathway. Acts upstream of or within oligopeptide transport. Located in plasma membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; nose; and respiratory system. Orthologous to human SLC15A2 (solute carrier family 15 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 7.8), frontal lobe adult (RPKM 3.5) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.97 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (36570523..36605506, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (36750161..36785158, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that SLC15A2 mediates the transport of bacterially derived di/tripeptides to enhance the nucleotide-binding oligomerization domain-dependent immune response in mouse bone marrow-derived macrophages
Title: SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain-Dependent Immune Response in Mouse Bone Marrow-Derived Macrophages.
We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate
Title: Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.
JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2.
Title: Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
The study presents a pharmacokinetic model to quantitate the distribution kinetics of glycylsarcosine, a substrate of PepT2, in blood, cerebrospinal fluid and kidney in wild-type and PepT2 knockout mice.
Title: Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.
Report influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
Title: Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.
PEPT2 to be the dominant transporter for the reabsorption of di- and tripeptides and its pharmacological substrates in the organism, and for the removal of these substrates from the cerebrospinal fluid
Title: Peptide transporters and their roles in physiological processes and drug disposition.
Astrocytes from neonatal PEPT2-/- mice had reduced ALA and carnosine uptake compared to PEPT2+/+ mice. Results demonstrate that PEPT2 is the primary transporter responsible for the astrocytic uptake of ALA and carnosine.
Title: PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes.
PEPT2 is the main system responsible for tubular reabsorption of peptide-bound amino acids, although this does not lead to major changes in renal excretion of protein or free amino acids.
Title: Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.
PEPT2 is responsible for dipeptide uptake in choroid plexus tissue
Title: Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.
Peptide transport in the mammary gland
Title: Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

BF405220 (e-PCR)
- UniSTS:247834

BB244383 (e-PCR)
- UniSTS:209215

RH126446 (e-PCR)
- UniSTS:163154

C78862 (e-PCR)
- UniSTS:180903

Slc15a2 (e-PCR), detects polymorphism
- UniSTS:546997

NoName (e-PCR)
- UniSTS:237507

Slc15a2 (e-PCR), detects polymorphism
- UniSTS:186344

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables high-affinity oligopeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables peptide:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables tripeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables tripeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in dipeptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dipeptide transport	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligopeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidoglycan transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tripeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in tripeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: solute carrier family 15 member 2

Names: kidney H(+)/peptide cotransporter; peptide transporter 2; proton-dependent high affinity oligopeptide transporter PepT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145899.2 → NP_001139371.2 solute carrier family 15 member 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate segment at the 3' end compared to variant 1, which results in a frameshift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC117662, AEKQ02018542

Consensus CDS

CCDS49842.1

UniProtKB/TrEMBL

E9Q329, Q80XC0, Q9CXC0

Related

ENSMUSP00000132029.3, ENSMUST00000164579.9

Conserved Domains (1) summary

cl28910
Location:54 → 243

MFS; Major Facilitator Superfamily
NM_021301.4 → NP_067276.3 solute carrier family 15 member 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC117662, AEKQ02018542

Consensus CDS

CCDS28156.1

UniProtKB/Swiss-Prot

Q9ES07

UniProtKB/TrEMBL

E9QMN8, Q9JM03

Related

ENSMUSP00000023616.4, ENSMUST00000023616.11

Conserved Domains (1) summary

TIGR00926
Location:69 → 707

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

36570523..36605506 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522430.4 → XP_006522493.1 solute carrier family 15 member 2 isoform X1

See identical proteins and their annotated locations for XP_006522493.1

Conserved Domains (1) summary

TIGR00926
Location:2 → 403

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)