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    ZNF462 zinc finger protein 462 [ Homo sapiens (human) ]

    Gene ID: 58499, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF462provided by HGNC
    Official Full Name
    zinc finger protein 462provided by HGNC
    Primary source
    HGNC:HGNC:21684
    See related
    Ensembl:ENSG00000148143 MIM:617371; AllianceGenome:HGNC:21684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WSKA; ZFPIP; Zfp462
    Summary
    The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in testis (RPKM 2.5), thyroid (RPKM 2.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF462 in Genome Data Viewer
    Location:
    9q31.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (106860158..107013634)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (119036267..119189919)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (109625447..109775915)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene COP1, E3 ubiquitin ligase pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28748 Neighboring gene uncharacterized LOC105376204 Neighboring gene RNA, 5S ribosomal pseudogene 292 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:109633482-109634681 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:109640709-109641456 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:109654807-109655306 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:109678392-109679591 Neighboring gene uncharacterized LOC340512 Neighboring gene ribosomal protein L7a pseudogene 44 Neighboring gene NANOG hESC enhancer GRCh37_chr9:109769611-109770112 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:109812053-109812571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20155 Neighboring gene APAF1 interacting protein pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:109892664-109893478 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:109893479-109894291 Neighboring gene importin subunit alpha-1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Weiss-Kruszka syndrome
    MedGen: CN294398 OMIM: 618619 GeneReviews: Weiss-Kruszka Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-01-16)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-01-16)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14960, FLJ45904, KIAA1803, DKFZp686B2325, DKFZp762N2316

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 462
    Names
    zinc finger PBX1-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052913.1 RefSeqGene

      Range
      5070..155538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347997.2NP_001334926.1  zinc finger protein 462 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL512593, AL590362, F13685
      Conserved Domains (2) summary
      sd00017
      Location:11621182
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:12181243
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. NM_021224.6NP_067047.4  zinc finger protein 462 isoform 1

      See identical proteins and their annotated locations for NP_067047.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL512593, BX648965, F13685
      Consensus CDS
      CCDS35096.1
      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
      Related
      ENSP00000277225.5, ENST00000277225.10
      Conserved Domains (1) summary
      sd00017
      Location:20272047
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      106860158..107013634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423662.1XP_047279618.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    2. XM_047423672.1XP_047279628.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    3. XM_047423680.1XP_047279636.1  zinc finger protein 462 isoform X4

    4. XM_047423685.1XP_047279641.1  zinc finger protein 462 isoform X6

    5. XM_006717212.5XP_006717275.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006717275.1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain
    6. XM_047423669.1XP_047279625.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    7. XM_047423676.1XP_047279632.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    8. XM_047423681.1XP_047279637.1  zinc finger protein 462 isoform X4

    9. XM_047423683.1XP_047279639.1  zinc finger protein 462 isoform X5

    10. XM_047423684.1XP_047279640.1  zinc finger protein 462 isoform X6

    11. XM_006717209.5XP_006717272.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006717272.1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain
    12. XM_047423668.1XP_047279624.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    13. XM_047423679.1XP_047279635.1  zinc finger protein 462 isoform X4

    14. XM_047423682.1XP_047279638.1  zinc finger protein 462 isoform X5

    15. XM_047423661.1XP_047279617.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    16. XM_006717215.5XP_006717278.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (1) summary
      sd00017
      Location:20872107
      ZF_C2H2; C2H2 Zn finger [structural motif]
    17. XM_006717216.5XP_006717279.1  zinc finger protein 462 isoform X3

      See identical proteins and their annotated locations for XP_006717279.1

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (1) summary
      sd00017
      Location:20272047
      ZF_C2H2; C2H2 Zn finger [structural motif]
    18. XM_047423663.1XP_047279619.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    19. XM_047423664.1XP_047279620.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    20. XM_047423677.1XP_047279633.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    21. XM_017014998.3XP_016870487.1  zinc finger protein 462 isoform X6

      Conserved Domains (2) summary
      sd00017
      Location:11621182
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:12181243
      zf-H2C2_5; C2H2-type zinc-finger domain
    22. XM_017014996.3XP_016870485.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain
    23. XM_047423670.1XP_047279626.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    24. XM_047423673.1XP_047279629.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    25. XM_024447629.1XP_024303397.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain
    26. XM_047423675.1XP_047279631.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    27. XM_017014997.3XP_016870486.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain
    28. XM_047423671.1XP_047279627.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    29. XM_047423678.1XP_047279634.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    30. XM_047423667.1XP_047279623.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    31. XM_047423666.1XP_047279622.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    32. XM_047423674.1XP_047279630.1  zinc finger protein 462 isoform X3

      UniProtKB/Swiss-Prot
      Q5T0T4, Q8N408, Q96JM2
      UniProtKB/TrEMBL
      Q63HJ5
    33. XM_047423665.1XP_047279621.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    34. XM_006717211.5XP_006717274.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006717274.1

      UniProtKB/TrEMBL
      Q63HJ5
      Conserved Domains (2) summary
      sd00017
      Location:20882108
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:21442169
      zf-H2C2_5; C2H2-type zinc-finger domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      119036267..119189919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363457.1XP_054219432.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    2. XM_054363438.1XP_054219413.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    3. XM_054363447.1XP_054219422.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    4. XM_054363464.1XP_054219439.1  zinc finger protein 462 isoform X6

    5. XM_054363460.1XP_054219435.1  zinc finger protein 462 isoform X4

    6. XM_054363462.1XP_054219437.1  zinc finger protein 462 isoform X5

    7. XM_054363451.1XP_054219426.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    8. XM_054363435.1XP_054219410.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    9. XM_054363465.1XP_054219440.1  zinc finger protein 462 isoform X6

    10. XM_054363459.1XP_054219434.1  zinc finger protein 462 isoform X4

    11. XM_054363434.1XP_054219409.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    12. XM_054363445.1XP_054219420.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    13. XM_054363458.1XP_054219433.1  zinc finger protein 462 isoform X4

    14. XM_054363461.1XP_054219436.1  zinc finger protein 462 isoform X5

    15. XM_054363456.1XP_054219431.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    16. XM_054363446.1XP_054219421.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    17. XM_054363450.1XP_054219425.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    18. XM_054363436.1XP_054219411.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    19. XM_054363439.1XP_054219414.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    20. XM_054363440.1XP_054219415.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    21. XM_054363448.1XP_054219423.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    22. XM_054363452.1XP_054219427.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    23. XM_054363463.1XP_054219438.1  zinc finger protein 462 isoform X6

    24. XM_054363443.1XP_054219418.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    25. XM_054363454.1XP_054219429.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    26. XM_054363437.1XP_054219412.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    27. XM_054363449.1XP_054219424.1  zinc finger protein 462 isoform X2

      UniProtKB/TrEMBL
      Q63HJ5
    28. XM_054363455.1XP_054219430.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    29. XM_054363444.1XP_054219419.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    30. XM_054363453.1XP_054219428.1  zinc finger protein 462 isoform X3

      UniProtKB/TrEMBL
      Q63HJ5
    31. XM_054363442.1XP_054219417.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5
    32. XM_054363441.1XP_054219416.1  zinc finger protein 462 isoform X1

      UniProtKB/TrEMBL
      Q63HJ5