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    RAP1GAP RAP1 GTPase activating protein [ Homo sapiens (human) ]

    Gene ID: 5909, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RAP1GAPprovided by HGNC
    Official Full Name
    RAP1 GTPase activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9858
    See related
    Ensembl:ENSG00000076864 MIM:600278; AllianceGenome:HGNC:9858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
    Summary
    This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in thyroid (RPKM 75.3), brain (RPKM 38.1) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RAP1GAP in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (21596221..21669357, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (21420130..21493311, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21922714..21995850, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21835859-21836429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21836430-21836999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:21860784-21861513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21863949-21864466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21864467-21864985 Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21895010-21895594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21900641-21901315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21901316-21901990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21904065-21904588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21917321-21917860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21917861-21918399 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21928741-21928970 Neighboring gene long intergenic non-protein coding RNA 2596 Neighboring gene Sharpr-MPRA regulatory region 12165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21937517-21938264 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21939576-21939868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21945135-21945976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21958265-21959233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21961087-21961835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21960338-21961086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21966135-21966964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21977615-21978365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21992551-21993051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 387 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:21996570-21997769 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene uncharacterized LOC124904736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:22099067-22099566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 337 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:22108688-22109459 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:22109460-22110230 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:22112153-22112327 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:22137244-22137394 Neighboring gene Sharpr-MPRA regulatory region 6146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:22148116-22148982 Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene heparan sulfate proteoglycan 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Rubinfeld B, et al. Cell, 1991 Jun 14. PMID 1904317
    2. Rap1GAP regulates renal cell carcinoma invasion. Kim WJ, et al. Cancer Lett, 2012 Jul 1. PMID 22266190, Free PMC Article
    3. Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro. Qiu T, et al. Oncol Rep, 2012 Aug. PMID 22614916
    4. RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. Dong X, et al. Endocr Relat Cancer, 2012 Aug. PMID 22696507, Free PMC Article
    5. Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Tsygankova OM, et al. Mol Cell Biol, 2010 Jul. PMID 20439492, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
      Title: Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
    2. CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
      Title: CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
    3. Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
      Title: Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
    4. Downregulation of Rap1GAP Expression Activates the TGF-beta/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
      Title: Downregulation of Rap1GAP Expression Activates the TGF-β/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
    5. RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer.
      Title: RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer.
    6. Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
      Title: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
    7. This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS
      Title: Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
    8. Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer.
      Title: Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients.
    9. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
      Title: Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
    10. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC).
      Title: Rap1GAP inhibits tumor progression in endometrial cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0474

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response TAS
    Traceable Author Statement
    more info
    		  
    involved_in cellular response to glial cell derived neurotrophic factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of thyroid gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rap1 GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029807.1 RefSeqGene

      Range
      5007..78143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145657.3 → NP_001139129.1  rap1 GTPase-activating protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001139129.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform 4. Isoform 2 is also known as isoform b.
      Source sequence(s)
      AB007943, BC035030, HY115754
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Related
      ENSP00000441661.1, ENST00000542643.6
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    2. NM_001145658.3 → NP_001139130.1  rap1 GTPase-activating protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001139130.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (1) is longer at the N-terminus and lacks an alternate internal segment compared to isoform 4. Isoform 1 is also known as isoform a.
      Source sequence(s)
      AL359815, BC035030, BC054490, BM739021, BP200029, CV574545
      Consensus CDS
      CCDS53277.1
      UniProtKB/TrEMBL
      J3KPC5
      Related
      ENSP00000434033.2, ENST00000495204.5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    3. NM_001330383.3 → NP_001317312.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4). Isoform 4 is also known as isoform d.
      Source sequence(s)
      AB007943, BC035030, BI546732, BM742308, HY115754
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    4. NM_001350524.2 → NP_001337453.1  rap1 GTPase-activating protein 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Isoform 5 is also known as isoform e.
      Source sequence(s)
      AB007943, AI301600, BC035030, BI546732, HY115754
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    5. NM_001350525.2 → NP_001337454.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: Isoform 6 is also known as isoform f.
      Source sequence(s)
      AB007943, AI301600, BC035030, BX094488, HY115754
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    6. NM_001350526.2 → NP_001337455.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AB007943, AF114047, AI301600, AL359815, BC035030, BX094488, HY115754
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    7. NM_001350527.2 → NP_001337456.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB007943, AI301600, BC035030, BM821324, BX094488, HY115754, HY136222
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    8. NM_001350528.2 → NP_001337457.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: Isoform 7 is also known as isoform g.
      Source sequence(s)
      AB007943, AI301600, BC035030, BM821324, BX094488, CF139631, HY115754, HY136222
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    9. NM_001388200.1 → NP_001375129.1  rap1 GTPase-activating protein 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    10. NM_001388201.1 → NP_001375130.1  rap1 GTPase-activating protein 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    11. NM_001388202.1 → NP_001375131.1  rap1 GTPase-activating protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    12. NM_001388203.1 → NP_001375132.1  rap1 GTPase-activating protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    13. NM_001388204.1 → NP_001375133.1  rap1 GTPase-activating protein 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    14. NM_001388205.1 → NP_001375134.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Related
      ENSP00000363895.2, ENST00000374763.6
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    15. NM_001388206.1 → NP_001375135.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    16. NM_001388207.1 → NP_001375136.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    17. NM_001388208.1 → NP_001375137.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    18. NM_001388209.1 → NP_001375138.1  rap1 GTPase-activating protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS81276.1
      UniProtKB/TrEMBL
      J3KPC5, X6R8W7
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    19. NM_001388210.1 → NP_001375139.1  rap1 GTPase-activating protein 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    20. NM_001388211.1 → NP_001375140.1  rap1 GTPase-activating protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    21. NM_001388212.1 → NP_001375141.1  rap1 GTPase-activating protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    22. NM_001388213.1 → NP_001375142.1  rap1 GTPase-activating protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    23. NM_001388214.1 → NP_001375143.1  rap1 GTPase-activating protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    24. NM_001388215.1 → NP_001375144.1  rap1 GTPase-activating protein 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 366
      Rap_GAP; Rap/ran-GAP

    25. NM_001388216.1 → NP_001375145.1  rap1 GTPase-activating protein 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    26. NM_001388217.1 → NP_001375146.1  rap1 GTPase-activating protein 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      Q49AP2
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    27. NM_001388218.1 → NP_001375147.1  rap1 GTPase-activating protein 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (3) summary
      PTZ00449
      Location:456 → 603
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    28. NM_001388219.1 → NP_001375148.1  rap1 GTPase-activating protein 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:183 → 362
      Rap_GAP; Rap/ran-GAP

    29. NM_001388220.1 → NP_001375149.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    30. NM_001388221.1 → NP_001375150.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    31. NM_001388222.1 → NP_001375151.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    32. NM_001388223.1 → NP_001375152.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    33. NM_001388224.1 → NP_001375153.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    34. NM_001388225.1 → NP_001375154.1  rap1 GTPase-activating protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    35. NM_001388226.1 → NP_001375155.1  rap1 GTPase-activating protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    36. NM_001388227.1 → NP_001375156.1  rap1 GTPase-activating protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    37. NM_001388228.1 → NP_001375157.1  rap1 GTPase-activating protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    38. NM_001388229.1 → NP_001375158.1  rap1 GTPase-activating protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    39. NM_001388230.1 → NP_001375159.1  rap1 GTPase-activating protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS53276.1
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:1 → 17
      GoLoco; GoLoco motif

    40. NM_001388231.1 → NP_001375160.1  rap1 GTPase-activating protein 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (1) summary
      pfam02145
      Location:202 → 381
      Rap_GAP; Rap/ran-GAP

    41. NM_001388233.1 → NP_001375162.1  rap1 GTPase-activating protein 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:198 → 377
      Rap_GAP; Rap/ran-GAP

    42. NM_001388234.1 → NP_001375163.1  rap1 GTPase-activating protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 373
      Rap_GAP; Rap/ran-GAP

    43. NM_001388235.1 → NP_001375164.1  rap1 GTPase-activating protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 373
      Rap_GAP; Rap/ran-GAP

    44. NM_001388236.1 → NP_001375165.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    45. NM_001388237.1 → NP_001375166.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    46. NM_001388238.1 → NP_001375167.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    47. NM_001388239.1 → NP_001375168.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    48. NM_001388240.1 → NP_001375169.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    49. NM_001388241.1 → NP_001375170.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Related
      ENSP00000363893.2, ENST00000374761.6
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    50. NM_001388242.1 → NP_001375171.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    51. NM_001388243.1 → NP_001375172.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    52. NM_001388244.1 → NP_001375173.1  rap1 GTPase-activating protein 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:183 → 362
      Rap_GAP; Rap/ran-GAP

    53. NM_001388245.1 → NP_001375174.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    54. NM_001388246.1 → NP_001375175.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    55. NM_001388247.1 → NP_001375176.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    56. NM_001388248.1 → NP_001375177.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    57. NM_001388249.1 → NP_001375178.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    58. NM_001388250.1 → NP_001375179.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    59. NM_001388251.1 → NP_001375180.1  rap1 GTPase-activating protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    60. NM_001388252.1 → NP_001375181.1  rap1 GTPase-activating protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    61. NM_001388253.1 → NP_001375182.1  rap1 GTPase-activating protein 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 373
      Rap_GAP; Rap/ran-GAP

    62. NM_001388254.1 → NP_001375183.1  rap1 GTPase-activating protein 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    63. NM_001388255.1 → NP_001375184.1  rap1 GTPase-activating protein 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    64. NM_001388256.1 → NP_001375185.1  rap1 GTPase-activating protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 366
      Rap_GAP; Rap/ran-GAP

    65. NM_001388258.1 → NP_001375187.1  rap1 GTPase-activating protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 366
      Rap_GAP; Rap/ran-GAP

    66. NM_001388259.1 → NP_001375188.1  rap1 GTPase-activating protein 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 373
      Rap_GAP; Rap/ran-GAP

    67. NM_001388261.1 → NP_001375190.1  rap1 GTPase-activating protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    68. NM_001388263.1 → NP_001375192.1  rap1 GTPase-activating protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    69. NM_001388264.1 → NP_001375193.1  rap1 GTPase-activating protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    70. NM_001388266.1 → NP_001375195.1  rap1 GTPase-activating protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    71. NM_001388267.1 → NP_001375196.1  rap1 GTPase-activating protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    72. NM_001388269.1 → NP_001375198.1  rap1 GTPase-activating protein 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (1) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

    73. NM_001388270.1 → NP_001375199.1  rap1 GTPase-activating protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    74. NM_001388273.1 → NP_001375202.1  rap1 GTPase-activating protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    75. NM_001388276.1 → NP_001375205.1  rap1 GTPase-activating protein 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (1) summary
      pfam02145
      Location:56 → 235
      Rap_GAP; Rap/ran-GAP

    76. NM_001388279.1 → NP_001375208.1  rap1 GTPase-activating protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (1) summary
      pfam02145
      Location:56 → 235
      Rap_GAP; Rap/ran-GAP

    77. NM_001388280.1 → NP_001375209.1  rap1 GTPase-activating protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (1) summary
      pfam02145
      Location:56 → 235
      Rap_GAP; Rap/ran-GAP

    78. NM_001388281.1 → NP_001375210.1  rap1 GTPase-activating protein 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Conserved Domains (1) summary
      pfam02145
      Location:56 → 235
      Rap_GAP; Rap/ran-GAP

    79. NM_001388282.1 → NP_001375211.1  rap1 GTPase-activating protein 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (1) summary
      pfam02145
      Location:172 → 351
      Rap_GAP; Rap/ran-GAP

    80. NM_001388283.1 → NP_001375212.1  rap1 GTPase-activating protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Related
      ENSP00000431364.1, ENST00000471600.6
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    81. NM_001388284.1 → NP_001375213.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    82. NM_001388285.1 → NP_001375214.1  rap1 GTPase-activating protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    83. NM_001388286.1 → NP_001375215.1  rap1 GTPase-activating protein 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 437
      Rap_GAP; Rap/ran-GAP

    84. NM_001388287.1 → NP_001375216.1  rap1 GTPase-activating protein 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    85. NM_001388288.1 → NP_001375217.1  rap1 GTPase-activating protein 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    86. NM_001388289.1 → NP_001375218.1  rap1 GTPase-activating protein 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    87. NM_001388290.1 → NP_001375219.1  rap1 GTPase-activating protein 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 452
      Rap_GAP; Rap/ran-GAP

    88. NM_001388291.1 → NP_001375220.1  rap1 GTPase-activating protein 1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 430
      Rap_GAP; Rap/ran-GAP

    89. NM_001388292.1 → NP_001375221.1  rap1 GTPase-activating protein 1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    90. NM_001388293.1 → NP_001375222.1  rap1 GTPase-activating protein 1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    91. NM_001388294.1 → NP_001375223.1  rap1 GTPase-activating protein 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    92. NM_001388295.1 → NP_001375224.1  rap1 GTPase-activating protein 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    93. NM_001388296.1 → NP_001375225.1  rap1 GTPase-activating protein 1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AL359815
      UniProtKB/TrEMBL
      J3KPC5
      Conserved Domains (2) summary
      smart00390
      Location:61 → 81
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275 → 454
      Rap_GAP; Rap/ran-GAP

    94. NM_002885.4 → NP_002876.2  rap1 GTPase-activating protein 1 isoform 3

      See identical proteins and their annotated locations for NP_002876.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4. Variants 3 and 8 encode the same protein (isoform 3). Isoform 3 is also known as isoform c.
      Source sequence(s)
      AB007943, AL359815, BC035030, HY115754, M64788
      Consensus CDS
      CCDS218.1
      UniProtKB/Swiss-Prot
      J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
      UniProtKB/TrEMBL
      J3KPC5
      Related
      ENSP00000363897.4, ENST00000374765.9
      Conserved Domains (2) summary
      smart00390
      Location:1 → 17
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211 → 390
      Rap_GAP; Rap/ran-GAP

    RNA

    1. NR_170899.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    2. NR_170900.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    3. NR_170901.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    4. NR_170902.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815
      Related
      ENST00000611549.4

    5. NR_170903.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    6. NR_170904.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    7. NR_170905.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    8. NR_170906.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    9. NR_170907.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    10. NR_170908.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    11. NR_170909.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    12. NR_170910.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    13. NR_170911.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    14. NR_170912.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    15. NR_170913.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    16. NR_170914.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    17. NR_170915.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    18. NR_170916.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    19. NR_170920.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    20. NR_170921.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    21. NR_170923.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    22. NR_170924.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    23. NR_170925.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    24. NR_170926.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    25. NR_170927.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    26. NR_170928.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    27. NR_170929.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359815

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      21596221..21669357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      21420130..21493311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47736.2 GenPept UniProtKB/Swiss-Prot:P47736

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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