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    Akirin1 akirin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 595134, updated on 9-Dec-2024

    Summary

    Official Symbol
    Akirin1provided by RGD
    Official Full Name
    akirin 1provided by RGD
    Primary source
    RGD:1585989
    See related
    EnsemblRapid:ENSRNOG00000026610 AllianceGenome:RGD:1585989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of satellite cell differentiation; and positive regulation of lamellipodium assembly. Predicted to be located in chromatin; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human AKIRIN1 (akirin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 265.4), Adrenal (RPKM 182.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Akirin1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (141274174..141289617, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135989378..136004782, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (141415226..141430627, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene uncharacterized LOC120103124 Neighboring gene rhomboid like 2 Neighboring gene uncharacterized LOC134479030

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in myoblast migration involved in skeletal muscle regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myoblast migration involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of satellite cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of skeletal muscle satellite cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030054.1NP_001025225.1  akirin-1

      See identical proteins and their annotated locations for NP_001025225.1

      Status: VALIDATED

      Source sequence(s)
      BF282685, BQ782380, CB761626, CO384190, CV107792, CV113375
      UniProtKB/TrEMBL
      A0A8I5Y994, A6IS36, D3ZTH4
      Related
      ENSRNOP00000037684.6, ENSRNOT00000034944.7
      Conserved Domains (1) summary
      cl41779
      Location:2191
      akirin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      141274174..141289617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288335.1XP_063144405.1  akirin-1 isoform X1

      UniProtKB/TrEMBL
      D3ZTH4