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    XRCC4 X-ray repair cross complementing 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 613590, updated on 27-Dec-2024

    Summary

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    Official Symbol
    XRCC4provided by VGNC
    Official Full Name
    X-ray repair cross complementing 4provided by VGNC
    Primary source
    VGNC:VGNC:37005
    See related
    Ensembl:ENSBTAG00000024275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See XRCC4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (82958902..83340016)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345839 Neighboring gene transmembrane protein 167A Neighboring gene microRNA mir-2463 Neighboring gene versican Neighboring gene uncharacterized LOC101902163 Neighboring gene hyaluronan and proteoglycan link protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148661

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA ligation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin V(D)J recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of DNA-dependent protein kinase-DNA ligase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair protein XRCC4
    Names
    X-ray repair cross complementing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081615.2 → NP_001075084.1  DNA repair protein XRCC4

      See identical proteins and their annotated locations for NP_001075084.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133433
      UniProtKB/TrEMBL
      A0AAA9S6L5, A2VDW3, F1N695
      Related
      ENSBTAP00000040350.3, ENSBTAT00000042719.5
      Conserved Domains (1) summary
      pfam06632
      Location:2 → 331
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      82958902..83340016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010807593.4 → XP_010805895.1  DNA repair protein XRCC4 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M1Z3
      Conserved Domains (1) summary
      pfam06632
      Location:2 → 299
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    2. XM_024994578.2 → XP_024850346.1  DNA repair protein XRCC4 isoform X5

      UniProtKB/TrEMBL
      A0AAA9S6L5, A0AAA9TWF9
      Related
      ENSBTAP00000102652.1, ENSBTAT00000134846.1
      Conserved Domains (1) summary
      pfam06632
      Location:2 → 297
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    3. XM_005209722.3 → XP_005209779.1  DNA repair protein XRCC4 isoform X2

      See identical proteins and their annotated locations for XP_005209779.1

      UniProtKB/TrEMBL
      A0AAA9S6L5, A2VDW3, F1N695
      Conserved Domains (1) summary
      pfam06632
      Location:2 → 331
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    4. XM_010807594.4 → XP_010805896.1  DNA repair protein XRCC4 isoform X4

      See identical proteins and their annotated locations for XP_010805896.1

      UniProtKB/TrEMBL
      A0AAA9S6L5, A0AAA9TS28
      Related
      ENSBTAP00000101400.1, ENSBTAT00000110836.1
      Conserved Domains (1) summary
      pfam06632
      Location:2 → 297
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    5. XM_059888371.1 → XP_059744354.1  DNA repair protein XRCC4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6L5, A0AAA9SCC5

    6. XM_059888370.1 → XP_059744353.1  DNA repair protein XRCC4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S6L5, A0AAA9SCC5
      Related
      ENSBTAP00000081180.1, ENSBTAT00000093425.1
    Nucleotide Protein Strain
    Heading Accession and Version

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