SCD5 stearoyl-CoA desaturase 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SCD5provided by VGNC
Official Full Name: stearoyl-CoA desaturase 5provided by VGNC
Primary source: VGNC:VGNC:34328
See related: BGD:BT11419; Ensembl:ENSBTAG00000022449
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (97461663..97637658, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This is the first study examining a potential role for SCD5 in providing 18:1n-9 for brain lipids.
Title: Bovine brain region-specific stearoyl-CoA desaturase expression and fatty acid composition.
This is the first report of potential regulators of SCD5 transcription.
Title: Regulation of the bovine SCD5 promoter by EGR2 and SREBP1.
In this paper, we describe for the first time a second SCD isoform in cattle, which appears to be an ortholog of human SCD5 rather than a homolog of bovine SCD1 or any of the described murine SCD isoforms
Title: Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: stearoyl-CoA desaturase 5

Names: acyl-CoA-desaturase 4; stearoyl-CoA 9-desaturase

NP_001070413.1

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076945.1 → NP_001070413.1 stearoyl-CoA desaturase 5

See identical proteins and their annotated locations for NP_001070413.1

Status: PROVISIONAL

Source sequence(s)

BC112711

UniProtKB/Swiss-Prot

Q2KIA4

Related

ENSBTAP00000025820.5, ENSBTAT00000025820.7

Conserved Domains (1) summary

cd03505
Location:76 → 316

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...