Acsf2 acyl-CoA synthetase family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acsf2provided by RGD
Official Full Name: acyl-CoA synthetase family member 2provided by RGD
Primary source: RGD:1562656
See related: EnsemblRapid:ENSRNOG00000003330 AllianceGenome:RGD:1562656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable medium-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in mitochondrion. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 219.5), Liver (RPKM 109.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80001389..80043796, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79504510..79546714, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82284719..82326771, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables medium-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: medium-chain acyl-CoA ligase ACSF2, mitochondrial

Names: acyl-CoA synthetase family member 2, mitochondrial

NP_001030123.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034951.3 → NP_001030123.1 medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q499N5

UniProtKB/TrEMBL

A0A8I6GEJ7

Related

ENSRNOP00000004673.4, ENSRNOT00000004673.6

Conserved Domains (1) summary

PRK08315
Location:57 → 615

PRK08315; AMP-binding domain protein; Validated