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    Zfp997 zinc finger protein 997 [ Mus musculus (house mouse) ]

    Gene ID: 628709, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp997provided by MGI
    Official Full Name
    zinc finger protein 997provided by MGI
    Primary source
    MGI:MGI:3642406
    See related
    Ensembl:ENSMUSG00000095909 AllianceGenome:MGI:3642406
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snerv2; Gm10324
    Summary
    Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF28 (zinc finger protein 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp997 in Genome Data Viewer
    Location:
    13 B3; 13 34.51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (66258188..66271523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66110374..66123709)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RING1 and YY1 binding protein, pseudogene Neighboring gene predicted gene, 21931 Neighboring gene upstream binding transcription factor, RNA polymerase I pseudogene Neighboring gene STARR-seq mESC enhancer starr_34861 Neighboring gene predicted gene, 45965 Neighboring gene vomeronasal 2, receptor, pseudogene 102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Treger RS, et al. Immunity, 2019 Feb 19. PMID 30709743, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 997
    Names
    zinc finger protein family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177832.1 → NP_001171303.1  zinc finger protein 997

      Status: PROVISIONAL

      Source sequence(s)
      AC192334
      UniProtKB/TrEMBL
      A0A571BGF1
      Related
      ENSMUSP00000158820.3, ENSMUST00000238623.3
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:129 → 564
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:525 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:145 → 170
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      66258188..66271523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247342.1 → XP_030103202.1  zinc finger protein 997 isoform X1

      Conserved Domains (5) summary
      COG5048
      Location:109 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:79 → 134
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:505 → 525
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1 → 24
      KRAB; KRAB box
      pfam13465
      Location:545 → 570
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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