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    Catspere1 cation channel sperm associated auxiliary subunit epsilon 1 [ Mus musculus (house mouse) ]

    Gene ID: 631584, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Catspere1provided by MGI
    Official Full Name
    cation channel sperm associated auxiliary subunit epsilon 1provided by MGI
    Primary source
    MGI:MGI:3647531
    See related
    Ensembl:ENSMUSG00000102483 AllianceGenome:MGI:3647531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm7068; Catspere; EG631584
    Summary
    Predicted to be involved in flagellated sperm motility and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Orthologous to human CATSPERE (catsper channel auxiliary subunit epsilon). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 11.9) See more
    Orthologs
    human all
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    Genomic context

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    See Catspere1 in Genome Data Viewer
    Location:
    1 H4; 1 82.82 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177635985..177789819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177808419..177962253)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30115 Neighboring gene STARR-seq mESC enhancer starr_03132 Neighboring gene sperm microtubule inner protein 3 Neighboring gene STARR-seq mESC enhancer starr_03133 Neighboring gene STARR-positive B cell enhancer ABC_E4395 Neighboring gene STARR-positive B cell enhancer ABC_E632 Neighboring gene STARR-seq mESC enhancer starr_03135 Neighboring gene adenylosuccinate synthase 2 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03137 Neighboring gene STARR-positive B cell enhancer ABC_E2589 Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312 Neighboring gene STARR-seq mESC enhancer starr_03139 Neighboring gene translin-associated factor X pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility. Chung JJ, et al. Elife, 2017 Feb 23. PMID 28226241, Free PMC Article
    2. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CatSper complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated auxiliary subunit epsilon
    Names
    C1orf101-like protein
    catSper-epsilon
    catSperepsilon
    cation channel sperm-associated protein subunit epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368823.1 → NP_001355752.1  cation channel sperm-associated auxiliary subunit epsilon precursor

      Status: VALIDATED

      Source sequence(s)
      AC157787, AC163217
      Consensus CDS
      CCDS87930.1
      UniProtKB/Swiss-Prot
      P0DP43
      UniProtKB/TrEMBL
      A0A5F8MPP5
      Related
      ENSMUSP00000159061.2, ENSMUST00000194528.3
      Conserved Domains (1) summary
      pfam15020
      Location:694 → 931
      CATSPERD; Cation channel sperm-associated protein subunit delta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      177635985..177789819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314031.2 → XP_017169520.1  cation channel sperm-associated auxiliary subunit epsilon isoform X2

      UniProtKB/Swiss-Prot
      P0DP43
      Conserved Domains (1) summary
      pfam15020
      Location:652 → 889
      CATSPERD; Cation channel sperm-associated protein subunit delta

    2. XM_006497084.3 → XP_006497147.1  cation channel sperm-associated auxiliary subunit epsilon isoform X1

      UniProtKB/Swiss-Prot
      P0DP43
      Conserved Domains (1) summary
      pfam15020
      Location:723 → 917
      CATSPERD; Cation channel sperm-associated protein subunit delta

    3. XM_006497087.1 → XP_006497150.1  cation channel sperm-associated auxiliary subunit epsilon isoform X5

    4. XM_030241928.1 → XP_030097788.1  cation channel sperm-associated auxiliary subunit epsilon isoform X6

    5. XM_030241929.1 → XP_030097789.1  cation channel sperm-associated auxiliary subunit epsilon isoform X7

      UniProtKB/TrEMBL
      A0A5F8MPD0

    6. XM_017314033.1 → XP_017169522.1  cation channel sperm-associated auxiliary subunit epsilon isoform X4

      Conserved Domains (1) summary
      pfam15020
      Location:508 → 745
      CATSPERD; Cation channel sperm-associated protein subunit delta

    7. XM_006497085.2 → XP_006497148.1  cation channel sperm-associated auxiliary subunit epsilon isoform X3

      UniProtKB/Swiss-Prot
      P0DP43
      Conserved Domains (1) summary
      pfam15020
      Location:543 → 780
      CATSPERD; Cation channel sperm-associated protein subunit delta

    RNA

    1. XR_001779559.1 RNA Sequence

    2. XR_001779564.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DP43.1 GenPept UniProtKB/Swiss-Prot:P0DP43

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