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    ERVK-6 endogenous retrovirus group K member 6, envelope [ Homo sapiens (human) ]

    Gene ID: 64006, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ERVK-6provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 6, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:13915
    See related
    MIM:605626; AllianceGenome:HGNC:13915
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    cORF; ERVK6; K-Rev; c-orf; envK2; HERV-K108; HERV-K(C7)
    Summary
    Enables RNA stem-loop binding activity and protein homodimerization activity. Involved in mRNA export from nucleus; positive regulation of gene expression; and protein homooligomerization. Located in cytoplasm and nucleolus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    7p22.1

    Bibliography

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    Related articles in PubMed

    1. Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K. Löwer R, et al. J Virol, 1995 Jan. PMID 7983704, Free PMC Article
    2. Rec (formerly Corf) function requires interaction with a complex, folded RNA structure within its responsive element rather than binding to a discrete specific binding site. Magin-Lachmann C, et al. J Virol, 2001 Nov. PMID 11581404, Free PMC Article
    3. Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7. Reus K, et al. Genomics, 2001 Mar 15. PMID 11401447
    4. The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain. Boese A, et al. FEBS Lett, 2001 Mar 30. PMID 11287007
    5. The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region. Yang J, et al. RNA, 2000 Nov. PMID 11105755, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
      Title: HIV-1 controllers exhibit an enhanced antiretroviral innate state characterised by overexpression of p21 and MCPIP1 and silencing of ERVK-6 RNA expression.
    2. Up-regulation of the endogenous retrovirus HERV-K initiates and sustains activation of the immune system and causes vascular changes associated with pulmonary arterial hypertension.
      Title: Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension.
    3. ERVK6 gene insertion polymorphisms are associated with lung cancer.
      Title: Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus.
    4. Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
      Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
    5. ERVK6 translocates Env into the endoplasmic reticulum lumen.
      Title: Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec.
    6. HERV-K rec has a role in disturbed germ cell development
      Title: Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • Endogenous retrovirus group K member 6 Env polyprotein
    • Envelope polyprotein
    • HERV-K (HML-2.HOM)
    • HERV-K(C7) envelope protein
    • HERV-K(HML-2.HOM) envelope protein
    • HERV-K108 envelope protein
    • HERV-K_7p22.1 provirus Rec protein
    • HERV-K_7p22.1 provirus ancestral Env polyprotein
    • HERV-K_7p22.1 provirus ancestral Pol protein
    • HERV-K_7p22.1 provirus ancestral Pro protein
    • Rev-like protein
    • Rev/Rex homolog
    • endogenous retroviral sequence K, 6
    • endogenous retrovirus group K, member 6
    • envelope glycoprotein
    • envelope protein

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in syncytium formation by plasma membrane fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001007236.1: Suppressed sequence

      Description
      NM_001007236.1: This RefSeq was permanently discontinued as it represents an expressed retrovirus and is considered out of scope.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69383.1 GenPept UniProtKB/Swiss-Prot:Q69383
    Q69384.1 GenPept UniProtKB/Swiss-Prot:Q69384
    Q7LDI9.3 GenPept UniProtKB/Swiss-Prot:Q7LDI9
    Q9BXR3.2 GenPept UniProtKB/Swiss-Prot:Q9BXR3
    Q9Y6I0.2 GenPept UniProtKB/Swiss-Prot:Q9Y6I0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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