NOL6 nucleolar protein 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOL6provided by HGNC
Official Full Name: nucleolar protein 6provided by HGNC
Primary source: HGNC:HGNC:19910
See related: Ensembl:ENSG00000165271 MIM:611532; AllianceGenome:HGNC:19910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NRAP; UTP22; bA311H10.1
Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 9.6), skin (RPKM 6.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.3

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (33461353..33473924, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (33479851..33492421, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (33461351..33473922, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
Title: NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.
Title: Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CURI complex	IBA Inferred from Biological aspect of Ancestor more info
part_of UTP-C complex	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleolar protein 6

Names: nucleolar RNA-associated protein; nucleolar protein 6 (RNA-associated); nucleolar protein family 6 (RNA-associated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022917.5 → NP_075068.2 nucleolar protein 6 isoform alpha

See identical proteins and their annotated locations for NP_075068.2

Status: REVIEWED

Description

Transcript Variant: This variant (alpha) encodes the longest isoform (alpha), also known as the long isoform.

Source sequence(s)

AF361079, BC008852, CB267269

Consensus CDS

CCDS6543.1

UniProtKB/Swiss-Prot

Q5T5M3, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675, Q9H6R4

UniProtKB/TrEMBL

B4DF80

Related

ENSP00000297990.4, ENST00000297990.9

Conserved Domains (6) summary

pfam03813
Location:178 → 320

Nrap; Nrap protein domain 1

pfam17403
Location:323 → 463

Nrap_D2; Nrap protein PAP/OAS-like domain

pfam17404
Location:466 → 629

Nrap_D3; Nrap protein domain 3

pfam17405
Location:641 → 846

Nrap_D4; Nrap protein nucleotidyltransferase domain 4

pfam17406
Location:848 → 1003

Nrap_D5; Nrap protein PAP/OAS1-like domain 5

pfam17407
Location:1005 → 1137

Nrap_D6; Nrap protein domain 6
NM_139235.4 → NP_631981.2 nucleolar protein 6 isoform gamma

See identical proteins and their annotated locations for NP_631981.2

Status: REVIEWED

Description

Transcript Variant: This variant (gamma) lacks nine exons in the 3' region compared to variant alpha. The encoded isoform (gamma), also known as the short isoform, has a unique C-terminus compared to the alpha isoform.

Source sequence(s)

AF361081, BC008852, CB267269

Consensus CDS

CCDS6544.1

UniProtKB/Swiss-Prot

Q9H6R4

Related

ENSP00000313978.4, ENST00000353159.6

Conserved Domains (1) summary

pfam03813
Location:165 → 654

Nrap; Nrap protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

33461353..33473924 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047423740.1 → XP_047279696.1 nucleolar protein 6 isoform X1

UniProtKB/TrEMBL

B4DF80

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

33479851..33492421 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363572.1 → XP_054219547.1 nucleolar protein 6 isoform X1

UniProtKB/TrEMBL

B4DF80

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_130793.3: Suppressed sequence

Description

NM_130793.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.