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    SCFV single-chain Fv fragment [ Homo sapiens (human) ]

    Gene ID: 652070, updated on 25-Jun-2020

    Summary

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    Gene symbol
    SCFV
    Gene description
    single-chain Fv fragment
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    chromosome: 14

    Bibliography

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    Related articles in PubMed

    1. Exploiting bias in a non-immune human antibody library to predict antigenicity. Ackerman ME, et al. Protein Eng Des Sel, 2011 Nov. PMID 21908549
    2. Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation. Stoll P, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17322097
    3. Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli. Kou G, et al. Protein Expr Purif, 2007 Mar. PMID 17027283
    4. Complement recruitment using bispecific diabodies. Kontermann RE, et al. Nat Biotechnol, 1997 Jul. PMID 9219263
    5. Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity. Liu Y, et al. Neoplasia, 2006 Feb. PMID 16611405, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A non-immune human scFv antibody library to predict antigenicity was studied.
      Title: Exploiting bias in a non-immune human antibody library to predict antigenicity.
    2. GrB/scFvMEL, a fusion protein composed of human granzyme B (GrB) and the single-chain antibody scFvMEL, targets melanoma gp240 antigen and exerts impressive cytotoxic effects by inducing apoptosis.
      Title: Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity.
    3. The novel clot-targeting approach of anticoagulants via single-chain antibody directed against a LIBS-epitope on GPIIb/IIIa promises effective anticoagulation with reduced bleeding risk.
      Title: Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation.
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • immunglobulin heavy chain variable region
    Nucleotide Protein
    Heading Accession and Version

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