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    Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gapdhsprovided by RGD
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenase, spermatogenicprovided by RGD
    Primary source
    RGD:620150
    See related
    EnsemblRapid:ENSRNOG00000021009 AllianceGenome:RGD:620150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gapds; gapdh-2
    Summary
    Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in spermatid development. Located in motile cilium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDHS (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 673.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gapdhs in Genome Data Viewer
    Location:
    1q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95106516..95125918, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85979096..85994153, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89180063..89195347, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene transmembrane protein 147 Neighboring gene suprabasin Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Preferential localization of rat GAPDS on the ribs of fibrous sheath of sperm flagellum and its expression during flagellar formation. Tanii I, et al. Acta Histochem Cytochem, 2007 Feb 27. PMID 17375205, Free PMC Article
    2. Fibrous sheath of mammalian spermatozoa. Eddy EM, et al. Microsc Res Tech, 2003 May 1. PMID 12672126
    3. Location and characterization of GAPDS in male reproduction. Liu J, et al. Urol Int, 2013. PMID 23306140
    4. Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis. Welch JE, et al. Mol Reprod Dev, 2006 Aug. PMID 16700075
    5. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Miki K, et al. Proc Natl Acad Sci U S A, 2004 Nov 23. PMID 15546993, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatid development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase, testis-specific
    Names
    glyceraldehyde-3-phosphate dehydrogenase type 2
    spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2
    spermatogenic glyceraldehyde-3-phosphate dehydrogenase
    NP_076454.1
    XP_006228852.1
    XP_006228853.1
    XP_038946116.1
    XP_063129215.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023964.1 → NP_076454.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific

      See identical proteins and their annotated locations for NP_076454.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ297631
      UniProtKB/Swiss-Prot
      Q9ESV6
      Related
      ENSRNOP00000028518.4, ENSRNOT00000028518.8
      Conserved Domains (3) summary
      COG0057
      Location:102 → 432
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:102 → 248
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:253 → 410
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      95106516..95125918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228791.5 → XP_006228853.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X2

      Conserved Domains (3) summary
      COG0057
      Location:94 → 424
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:94 → 240
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:245 → 402
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    2. XM_006228790.5 → XP_006228852.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1

      See identical proteins and their annotated locations for XP_006228852.1

      UniProtKB/TrEMBL
      B1WBQ8, F7FCA4
      Related
      ENSRNOP00000059802.1, ENSRNOT00000067813.3
      Conserved Domains (3) summary
      COG0057
      Location:102 → 432
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:102 → 248
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:253 → 410
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    3. XM_063273145.1 → XP_063129215.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X3

    4. XM_039090188.2 → XP_038946116.1  glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X4

      Conserved Domains (1) summary
      PLN02272
      Location:1 → 287
      PLN02272; glyceraldehyde-3-phosphate dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESV6.1 GenPept UniProtKB/Swiss-Prot:Q9ESV6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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