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    Exosc7 exosome component 7 [ Mus musculus (house mouse) ]

    Gene ID: 66446, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Exosc7provided by MGI
    Official Full Name
    exosome component 7provided by MGI
    Primary source
    MGI:MGI:1913696
    See related
    Ensembl:ENSMUSG00000025785 AllianceGenome:MGI:1913696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0116; 2610002K22Rik
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytosol and nucleolus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including brain; genitourinary system; gut; submandibular gland primordium; and tooth. Orthologous to human EXOSC7 (exosome component 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.3), CNS E11.5 (RPKM 23.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exosc7 in Genome Data Viewer
    Location:
    9 F4; 9 73.8 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122942310..122965194)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123113231..123136129)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9856 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 (prostate) Neighboring gene zinc finger, DHHC domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_25557 Neighboring gene C-type lectin domain family 3, member b Neighboring gene predicted gene, 23323

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The yin and yang of the exosome. Butler JS. Trends Cell Biol, 2002 Feb. PMID 11849973
    2. Exosome complex components 1 and 2 are vital for early mammalian development. Srinivasan S, et al. Gene Expr Patterns, 2024 Mar. PMID 37940010,
    3. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Chen CY, et al. Cell, 2001 Nov 16. PMID 11719186
    4. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
    5. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nucleolar exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exosome complex exonuclease RRP42
    Names
    ribosomal RNA-processing protein 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081188.2 → NP_001074657.1  exosome complex exonuclease RRP42 isoform 1

      See identical proteins and their annotated locations for NP_001074657.1

      Status: VALIDATED

      Source sequence(s)
      AC134248
      Consensus CDS
      CCDS40815.1
      UniProtKB/Swiss-Prot
      Q4VBW5, Q9CT77, Q9D0M0
      UniProtKB/TrEMBL
      Q7TMX6
      Related
      ENSMUSP00000026891.5, ENSMUST00000026891.5
      Conserved Domains (1) summary
      cd11367
      Location:5 → 276
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

    2. NM_001418861.1 → NP_001405790.1  exosome complex exonuclease RRP42 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134248

    3. NM_001418862.1 → NP_001405791.1  exosome complex exonuclease RRP42 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134248

    4. NM_001418863.1 → NP_001405792.1  exosome complex exonuclease RRP42 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134248

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122942310..122965194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512207.5 → XP_006512270.1  exosome complex exonuclease RRP42 isoform X1

      See identical proteins and their annotated locations for XP_006512270.1

      Conserved Domains (1) summary
      cd11367
      Location:8 → 198
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025568.1: Suppressed sequence

      Description
      NM_025568.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0M0.2 GenPept UniProtKB/Swiss-Prot:Q9D0M0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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