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    Shisa5 shisa family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 66940, updated on 27-Nov-2024

    Summary

    Official Symbol
    Shisa5provided by MGI
    Official Full Name
    shisa family member 5provided by MGI
    Primary source
    MGI:MGI:1915044
    See related
    Ensembl:ENSMUSG00000025647 AllianceGenome:MGI:1915044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scotin; mShisa5; 2310008D10Rik; 6430628I05Rik
    Summary
    Predicted to enable WW domain binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in endoplasmic reticulum and nuclear envelope. Is expressed in blood vessel; cortical plate; extraembryonic component; foregut diverticulum; and meninges. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 466.2), mammary gland adult (RPKM 229.2) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Shisa5 in Genome Data Viewer
    Location:
    9 F2; 9 59.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108867635..108886860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109038567..109057792)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E192 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene urocortin 2 Neighboring gene STARR-seq mESC enhancer starr_25229 Neighboring gene STARR-positive B cell enhancer ABC_E5105 Neighboring gene STARR-positive B cell enhancer ABC_E5106 Neighboring gene STARR-positive B cell enhancer ABC_E10586 Neighboring gene STARR-positive B cell enhancer ABC_E10587 Neighboring gene STARR-positive B cell enhancer ABC_E5107 Neighboring gene predicted gene, 53191 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    protein shisa-5
    Names
    shisa homolog 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284332.1NP_001271261.1  protein shisa-5 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001271261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein (isoform 3).
      Source sequence(s)
      AC140383, AK212074
      Consensus CDS
      CCDS72309.1
      UniProtKB/Swiss-Prot
      Q9D7I0
      Related
      ENSMUSP00000107690.6, ENSMUST00000112059.10
      Conserved Domains (1) summary
      pfam13908
      Location:26192
      Shisa; Wnt and FGF inhibitory regulator
    2. NM_001357932.1NP_001344861.1  protein shisa-5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90665.1
      UniProtKB/TrEMBL
      A0A0G2JGP8, Q8BU09
      Related
      ENSMUSP00000143648.2, ENSMUST00000197099.5
      Conserved Domains (1) summary
      pfam13908
      Location:11123
      Shisa; Wnt and FGF inhibitory regulator
    3. NM_001357933.1NP_001344862.1  protein shisa-5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC140383, AK090357
      Consensus CDS
      CCDS90666.1
      UniProtKB/TrEMBL
      Q8BU09
      Related
      ENSMUSP00000142835.2, ENSMUST00000200515.5
      Conserved Domains (1) summary
      pfam13908
      Location:15127
      Shisa; Wnt and FGF inhibitory regulator
    4. NM_001357934.1NP_001344863.1  protein shisa-5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140383
      UniProtKB/TrEMBL
      A0A0G2JER0
      Conserved Domains (1) summary
      pfam13908
      Location:17103
      Shisa; Wnt and FGF inhibitory regulator
    5. NM_001357935.1NP_001344864.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 8-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000142978.2, ENSMUST00000198708.5
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    6. NM_001357936.1NP_001344865.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    7. NM_001357937.1NP_001344866.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 7, 8, and 10-12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    8. NM_001357939.1NP_001344868.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 7-9, 11, and 12, encodes isoform 7.
      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000143613.2, ENSMUST00000197483.5
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    9. NM_001357940.1NP_001344869.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 7-10 and 12, encodes isoform 7.
      Source sequence(s)
      AC140383, BF731565
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    10. NM_001357941.1NP_001344870.1  protein shisa-5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 7-11, encodes isoform 7.
      Source sequence(s)
      AA088083, AC140383
      Consensus CDS
      CCDS90667.1
      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Related
      ENSMUSP00000143599.2, ENSMUST00000196954.5
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    11. NM_025858.3NP_080134.1  protein shisa-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the coding region compared to variant 3. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 3.
      Source sequence(s)
      AC140383, AK033545
      Consensus CDS
      CCDS23543.1
      UniProtKB/Swiss-Prot
      Q8BJ86, Q8BJ87, Q8BLE9, Q8K4W3, Q91Z37, Q9CQP5, Q9D7I0
      Related
      ENSMUSP00000026737.8, ENSMUST00000026737.12
      Conserved Domains (1) summary
      pfam13908
      Location:26191
      Shisa; Wnt and FGF inhibitory regulator
    12. NM_026381.5NP_080657.1  protein shisa-5 isoform 2

      See identical proteins and their annotated locations for NP_080657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon and initiates translation at an alternate start codon compared to variant 3. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 3.
      Source sequence(s)
      AC140383, AK081060
      Consensus CDS
      CCDS40771.1
      UniProtKB/TrEMBL
      A0A0G2JER0
      Related
      ENSMUSP00000128901.2, ENSMUST00000154184.5
      Conserved Domains (1) summary
      pfam13908
      Location:288
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108867635..108886860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244508.2XP_030100368.1  protein shisa-5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    2. XM_030244506.1XP_030100366.1  protein shisa-5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JER0, A0A0G2JGK4
      Conserved Domains (1) summary
      pfam13908
      Location:189
      Shisa; Wnt and FGF inhibitory regulator
    3. XM_006512212.4XP_006512275.1  protein shisa-5 isoform X1

      See identical proteins and their annotated locations for XP_006512275.1

      Conserved Domains (1) summary
      pfam13908
      Location:39127
      Shisa; Wnt and FGF inhibitory regulator