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    Ccdc159 coiled-coil domain containing 159 [ Mus musculus (house mouse) ]

    Gene ID: 67119, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ccdc159provided by MGI
    Official Full Name
    coiled-coil domain containing 159provided by MGI
    Primary source
    MGI:MGI:1914369
    See related
    Ensembl:ENSMUSG00000006241 AllianceGenome:MGI:1914369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510048L02Rik
    Summary
    Involved in spermatid development. Acts upstream of or within several processes, including regulation of phosphatase activity; single fertilization; and sperm flagellum assembly. Is active in sperm head-tail coupling apparatus. Used to study male infertility due to acephalic spermatozoa. Orthologous to human CCDC159 (coiled-coil domain containing 159). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 21.1), CNS E18 (RPKM 4.9) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc159 in Genome Data Viewer
    Location:
    9 A3; 9 7.92 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21838767..21847168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21927471..21935872)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin-like 8 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene phospholipid phosphatase related 2 Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice†. Ge T, et al. Biol Reprod, 2024 May 9. PMID 38236177
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm head-tail coupling apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm head-tail coupling apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 159

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164614.1 → NP_001158086.1  coiled-coil domain-containing protein 159 isoform 1

      See identical proteins and their annotated locations for NP_001158086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK011114, AK042884
      Consensus CDS
      CCDS52738.1
      UniProtKB/Swiss-Prot
      Q0VBB7, Q8C963, Q9CXZ5, Q9D4W5
      Related
      ENSMUSP00000126474.2, ENSMUST00000170304.9

    2. NM_025977.3 → NP_080253.2  coiled-coil domain-containing protein 159 isoform 2

      See identical proteins and their annotated locations for NP_080253.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site at the 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when compared to isoform 1.
      Source sequence(s)
      AK011114, BC120702
      Consensus CDS
      CCDS40557.1
      UniProtKB/Swiss-Prot
      Q8C963
      Related
      ENSMUSP00000006403.7, ENSMUST00000006403.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21838767..21847168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C963.1 GenPept UniProtKB/Swiss-Prot:Q8C963

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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