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    Eph Eph receptor tyrosine kinase [ Drosophila simulans ]

    Gene ID: 6724716, updated on 22-May-2024

    Summary

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    Gene symbol
    Eph
    Gene description
    Eph receptor tyrosine kinase
    Locus tag
    Dsimw501_GD24409
    See related
    EnsemblRapid:LOC6724716
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Drosophila simulans
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    GD24409; GD24409-PB; GD24409-PC; GD24409-PD; GD24409-PE; GD24409-PF; GD24409-PG; GD24409-PH
    Orthologs
    fruit fly all
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    Genomic context

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    See Eph in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Prin_Dsim_3.1 (GCF_016746395.2) 4 NC_052524.2 (548157..558889)
    102 previous assembly Prin_Dsim_3.0 (GCF_016746395.1) 4 NC_052524.1 (548155..558892)

    Chromosome 4 - NC_052524.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120285206 Neighboring gene homeobox protein onecut Neighboring gene TGF-beta domain-containing family member maverick Neighboring gene sodium- and chloride-dependent GABA transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium, et al. Nature, 2007 Nov 8. PMID 17994087
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ephrin type-B receptor 1-B
    Names
    Dsim\GD24409
    Dsim\GD24409-PB
    Dsim\GD24409-PC
    Dsim\GD24409-PD
    Dsim\GD24409-PE
    Dsim\GD24409-PF
    Dsim\GD24409-PG
    Dsim\GD24409-PH
    dsim_GLEANR_8160

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Drosophila simulans Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Prin_Dsim_3.1

    Genomic

    1. NC_052524.2 Reference Prin_Dsim_3.1

      Range
      548157..558889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016180668.3 → XP_016037312.1  ephrin type-B receptor 1-B isoform X5

      UniProtKB/TrEMBL
      A0A0J9S0V0, A0A0J9USH3
      Related
      XP_016037312.1, XM_016180668.3
      Conserved Domains (8) summary
      smart00454
      Location:1040 → 1093
      SAM; Sterile alpha motif
      cd10319
      Location:86 → 261
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:537 → 624
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:737 → 1003
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      pfam00041
      Location:389 → 478
      fn3; Fibronectin type III domain
      pfam00536
      Location:1034 → 1093
      SAM_1; SAM domain (Sterile alpha motif)
      pfam07714
      Location:742 → 1000
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:645 → 737
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. XM_016180667.3 → XP_016037311.1  ephrin type-B receptor 1-B isoform X4

      UniProtKB/TrEMBL
      A0A0J9S133, A0A0J9S2G2
      Related
      XP_016037311.1, XM_016180667.3
      Conserved Domains (8) summary
      smart00454
      Location:1086 → 1139
      SAM; Sterile alpha motif
      cd10319
      Location:132 → 307
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:583 → 670
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:783 → 1049
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      pfam00041
      Location:435 → 524
      fn3; Fibronectin type III domain
      pfam00536
      Location:1080 → 1139
      SAM_1; SAM domain (Sterile alpha motif)
      pfam07714
      Location:788 → 1046
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:691 → 783
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    3. XM_016180670.3 → XP_016037314.1  ephrin type-B receptor 1-B isoform X5

      UniProtKB/TrEMBL
      A0A0J9S0V0, A0A0J9USH3
      Related
      XP_016037314.1, XM_016180670.3
      Conserved Domains (8) summary
      smart00454
      Location:1040 → 1093
      SAM; Sterile alpha motif
      cd10319
      Location:86 → 261
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:537 → 624
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:737 → 1003
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      pfam00041
      Location:389 → 478
      fn3; Fibronectin type III domain
      pfam00536
      Location:1034 → 1093
      SAM_1; SAM domain (Sterile alpha motif)
      pfam07714
      Location:742 → 1000
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:645 → 737
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    4. XM_016180666.3 → XP_016037310.3  ephrin type-B receptor 1-B isoform X2

      UniProtKB/TrEMBL
      A0A0J9S0U1
      Related
      XP_016037310.3, XM_016180666.3
      Conserved Domains (4) summary
      cd10319
      Location:131 → 306
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:433 → 522
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:775 → 1041
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      cl15755
      Location:1072 → 1126
      SAM_superfamily; SAM (Sterile alpha motif )

    5. XM_016180669.3 → XP_016037313.3  ephrin type-B receptor 1-B isoform X1

      UniProtKB/TrEMBL
      A0A0J9S2G2
      Related
      XP_016037313.3, XM_016180669.3
      Conserved Domains (4) summary
      cd10319
      Location:131 → 306
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:582 → 669
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:782 → 1048
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      cl15755
      Location:1079 → 1133
      SAM_superfamily; SAM (Sterile alpha motif )

    6. XM_016180671.3 → XP_016037315.3  ephrin type-B receptor 1-B isoform X3

      UniProtKB/TrEMBL
      A0A0J9S0U5
      Related
      XP_016037315.3, XM_016180671.3
      Conserved Domains (4) summary
      cd10319
      Location:131 → 306
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cd00063
      Location:433 → 522
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05033
      Location:766 → 1032
      PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases
      cl15755
      Location:1063 → 1117
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version

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