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    Slc25a26 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 [ Mus musculus (house mouse) ]

    Gene ID: 67582, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a26provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26provided by MGI
    Primary source
    MGI:MGI:1914832
    See related
    Ensembl:ENSMUSG00000045100 AllianceGenome:MGI:1914832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slc25a6; D6Bwg0781e; 4930433D19Rik; 4933433F13Rik
    Summary
    Predicted to enable S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity. Predicted to be involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.5), heart adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a26 in Genome Data Viewer
    Location:
    6 D2; 6 43.13 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (94477272..94581636)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (94500295..94604659)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16710 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16711 Neighboring gene microRNA 7041 Neighboring gene leucine-rich repeats and immunoglobulin-like domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:94587371-94587480 Neighboring gene VISTA enhancer mm1736 Neighboring gene prefoldin 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice. Cheng GP, et al. Oxid Med Cell Longev, 2022. PMID 35464759, Free PMC Article
    2. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Clark KJ, et al. Genesis, 2004 Aug. PMID 15286994
    3. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. Geurts AM, et al. BMC Biotechnol, 2006 Jun 26. PMID 16800892, Free PMC Article
    4. Transposon mutagenesis of the mouse germline. Carlson CM, et al. Genetics, 2003 Sep. PMID 14504232, Free PMC Article
    5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice.
      Title: Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Transposon induced (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosyl-L-methionine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosyl-L-methionine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosyl-L-methionine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in S-adenosyl-L-methionine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of macromolecule methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial S-adenosylmethionine carrier protein
    Names
    S-adenosylmethionine mitochondrial carrier protein
    SAM carrier
    mitochondrial S-adenosylmethionine transporter
    solute carrier family 25 member 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026255.5 → NP_080531.2  mitochondrial S-adenosylmethionine carrier protein

      See identical proteins and their annotated locations for NP_080531.2

      Status: VALIDATED

      Source sequence(s)
      AC122272, AK015299, BB852792, BU700917
      Consensus CDS
      CCDS20379.1
      UniProtKB/Swiss-Prot
      Q5U680, Q8JZT2
      Related
      ENSMUSP00000058028.9, ENSMUST00000061118.11
      Conserved Domains (2) summary
      PTZ00168
      Location:9 → 258
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:2 → 82
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      94477272..94581636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506517.5 → XP_006506580.1  mitochondrial S-adenosylmethionine carrier protein isoform X1

      Conserved Domains (1) summary
      PTZ00168
      Location:9 → 243
      PTZ00168; mitochondrial carrier protein; Provisional

    2. XM_006506518.5 → XP_006506581.1  mitochondrial S-adenosylmethionine carrier protein isoform X2

      Conserved Domains (1) summary
      PTZ00168
      Location:9 → 207
      PTZ00168; mitochondrial carrier protein; Provisional

    3. XM_006506519.5 → XP_006506582.1  mitochondrial S-adenosylmethionine carrier protein isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:4 → 80
      Mito_carr; Mitochondrial carrier protein

    4. XM_006506523.5 → XP_006506586.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

      Conserved Domains (1) summary
      PTZ00168
      Location:9 → 154
      PTZ00168; mitochondrial carrier protein; Provisional

    5. XM_036152276.1 → XP_036008169.1  mitochondrial S-adenosylmethionine carrier protein isoform X4

      Conserved Domains (1) summary
      PTZ00168
      Location:9 → 151
      PTZ00168; mitochondrial carrier protein; Provisional

    6. XM_011241446.4 → XP_011239748.1  mitochondrial S-adenosylmethionine carrier protein isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:4 → 80
      Mito_carr; Mitochondrial carrier protein

    7. XM_006506524.5 → XP_006506587.1  mitochondrial S-adenosylmethionine carrier protein isoform X7

      Conserved Domains (1) summary
      pfam00153
      Location:59 → 131
      Mito_carr; Mitochondrial carrier protein

    RNA

    1. XR_003956252.2 RNA Sequence

    2. XR_868874.4 RNA Sequence

    3. XR_868875.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U680.2 GenPept UniProtKB/Swiss-Prot:Q5U680

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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