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    Slc22a16 solute carrier family 22 member 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682934, updated on 9-Dec-2024

    Summary

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    Symbol
    Slc22a16provided by RGD
    Full Name
    solute carrier family 22 member 16provided by RGD
    Primary source
    RGD:1592810
    See related
    EnsemblRapid:ENSRNOG00000063767 AllianceGenome:RGD:1592810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable amine transmembrane transporter activity; carnitine transmembrane transporter activity; and spermidine transmembrane transporter activity. Predicted to be involved in several processes, including carnitine transmembrane transport; flagellated sperm motility; and spermidine transmembrane transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in cytosol and plasma membrane. Orthologous to human SLC22A16 (solute carrier family 22 member 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 74.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc22a16 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45527275..45647675)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43972808..44068447)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45658398..45669192)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene vasculin-like protein 1 Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 19 Neighboring gene D-aspartate oxidase Neighboring gene methyltransferase like 24 Neighboring gene uncharacterized LOC120098819

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the organic cation transporter SLC22A16: a doxorubicin importer. Okabe M, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15963465
    2. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. Enomoto A, et al. J Biol Chem, 2002 Sep 27. PMID 12089149
    3. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, et al. Pharmacogenet Genomics, 2011 Jul. PMID 21048526, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnitine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spermidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carnitine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within carnitine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnitine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 16
    Names
    solute carrier family 22 (organic cation/carnitine transporter), member 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432342.1 → NP_001419271.1  solute carrier family 22 member 16

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZMN2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45527275..45647675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099170.2 → XP_038955098.1  solute carrier family 22 member 16 isoform X1

      Related
      ENSRNOP00000082507.2, ENSRNOT00000115027.2
      Conserved Domains (2) summary
      PHA03169
      Location:645 → 852
      PHA03169; hypothetical protein; Provisional
      cl28910
      Location:118 → 528
      MFS; Major Facilitator Superfamily

    2. XM_063279637.1 → XP_063135707.1  solute carrier family 22 member 16 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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