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    Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 [ Mus musculus (house mouse) ]

    Gene ID: 68375, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ndufa8provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A8provided by MGI
    Primary source
    MGI:MGI:1915625
    See related
    Ensembl:ENSMUSG00000026895 AllianceGenome:MGI:1915625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CI-19kD; CI-PGIV; 0610033L03Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in alimentary system; axial skeleton; liver; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 140.9), kidney adult (RPKM 86.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa8 in Genome Data Viewer
    Location:
    2 B; 2 24.13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35926336..35939350, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36036324..36049338, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase-like family, member 11 Neighboring gene predicted gene, 35396 Neighboring gene STARR-positive B cell enhancer ABC_E10098 Neighboring gene STARR-seq mESC enhancer starr_04294 Neighboring gene STARR-seq mESC enhancer starr_04295 Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene predicted gene, 39798 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
    NADH-ubiquinone oxidoreductase 19 kDa subunit
    complex I-19kD
    complex I-PGIV
    NP_080979.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026703.3NP_080979.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

      See identical proteins and their annotated locations for NP_080979.1

      Status: VALIDATED

      Source sequence(s)
      AL773525
      Consensus CDS
      CCDS15967.1
      UniProtKB/Swiss-Prot
      A2AL45, Q9DCJ5
      UniProtKB/TrEMBL
      A0A1S6GWI0
      Related
      ENSMUSP00000065352.6, ENSMUST00000070112.6
      Conserved Domains (1) summary
      pfam06747
      Location:78111
      CHCH; CHCH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      35926336..35939350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)