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    Ints1 integrator complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 68510, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ints1provided by MGI
    Official Full Name
    integrator complex subunit 1provided by MGI
    Primary source
    MGI:MGI:1915760
    See related
    Ensembl:ENSMUSG00000029547 AllianceGenome:MGI:1915760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110015K06Rik
    Summary
    Acts upstream of or within several processes, including U2 snRNA 3'-end processing; inner cell mass cell proliferation; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in nucleus. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 35.7), adrenal adult (RPKM 20.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints1 in Genome Data Viewer
    Location:
    5 G2; 5 78.8 cM
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139737037..139761455, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139751282..139775702, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46926 Neighboring gene STARR-seq mESC enhancer starr_14696 Neighboring gene MICAL-like 2 Neighboring gene STARR-seq mESC enhancer starr_14697 Neighboring gene STARR-positive B cell enhancer ABC_E8087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene microRNA 7037 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene transmembrane protein 184a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. Nakayama M, et al. FASEB J, 2006 Aug. PMID 16807365
    2. Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death. Hata T, et al. Biochim Biophys Acta, 2007 Jul. PMID 17544522
    3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1440

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within U2 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within blastocyst growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrator complex subunit 1
    Names
    int1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026748.3 → NP_081024.4  integrator complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AC167333
      Consensus CDS
      CCDS57399.1
      UniProtKB/Swiss-Prot
      Q0KK58, Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7
      UniProtKB/TrEMBL
      A0A0G2JDG8, K3W4P2
      Related
      ENSMUSP00000143789.3, ENSMUST00000200393.5
      Conserved Domains (1) summary
      pfam12432
      Location:352 → 432
      DUF3677; Protein of unknown function (DUF3677)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139737037..139761455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504729.5 → XP_006504792.1  integrator complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JH17
      Related
      ENSMUSP00000072406.7, ENSMUST00000072607.9
      Conserved Domains (1) summary
      pfam12432
      Location:377 → 457
      DUF3677; Protein of unknown function (DUF3677)

    2. XM_006504728.5 → XP_006504791.1  integrator complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JH17
      Conserved Domains (1) summary
      pfam12432
      Location:377 → 457
      DUF3677; Protein of unknown function (DUF3677)

    3. XM_006504727.5 → XP_006504790.1  integrator complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JH17
      Conserved Domains (1) summary
      pfam12432
      Location:379 → 459
      DUF3677; Protein of unknown function (DUF3677)

    RNA

    1. XR_003955703.2 RNA Sequence

    2. XR_003955704.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4S8.2 GenPept UniProtKB/Swiss-Prot:Q6P4S8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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