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    L1td1 LINE-1 type transposase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685355, updated on 4-Jan-2025

    Summary

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    Official Symbol
    L1td1provided by RGD
    Official Full Name
    LINE-1 type transposase domain containing 1provided by RGD
    Primary source
    RGD:1595093
    See related
    EnsemblRapid:ENSRNOG00000050670 AllianceGenome:RGD:1595093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable single-stranded RNA binding activity. Predicted to be involved in retrotransposition. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ribonucleoprotein complex. Orthologous to human L1TD1 (LINE1 type transposase domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 2.8), Kidney (RPKM 2.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See L1td1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118488688..118501591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113373193..113386088)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (117347998..117361012)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 1 Neighboring gene PATJ, crumbs cell polarity complex component Neighboring gene uncharacterized LOC134486954 Neighboring gene KN motif and ankyrin repeat domains 4 Neighboring gene uncharacterized LOC134479012

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain. Moszczynska A, et al. Sci Rep, 2015 Oct 14. PMID 26463126, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in retrotransposition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LINE-1 type transposase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399842.1 → NP_001386771.1  LINE-1 type transposase domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      M0R3X5
      Related
      ENSRNOP00000098920.1, ENSRNOT00000123643.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      118488688..118501591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288429.1 → XP_063144499.1  LINE-1 type transposase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      M0R3X5

    2. XM_063288428.1 → XP_063144498.1  LINE-1 type transposase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      M0R3X5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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